{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T20:22:37Z","timestamp":1780518157888,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","issue":"23-24","license":[{"start":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T00:00:00Z","timestamp":1513728000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1037304"],"award-info":[{"award-number":["1037304"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteomics"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hookworm infection is a major tropical parasitic disease affecting almost 500 million people worldwide. These soil\u2010transmitted helminths can survive for many years in the intestine of the host, where they feed on blood, causing iron deficiency anemia and other complications. These parasites release a variety of molecules known as excretory\/secretory products (ESPs) that are involved in many different biological processes that govern parasite survival. Using a combination of separation techniques such as SDS\u2010PAGE and OFFGEL electrophoresis, in combination with state\u2010of\u2010the\u2010art mass spectrometry we have reanalyzed the dog hookworm,\n                    <jats:italic>Ancylostoma caninum<\/jats:italic>\n                    , ESPs (\n                    <jats:italic>Ac<\/jats:italic>\n                    ESP). We identified 315 proteins present in the\n                    <jats:italic>Ac<\/jats:italic>\n                    ESP, compared with just 105 identified in previous studies. The most highly represented family of proteins is the SCP\/TAPs (110 of the 315 proteins), and the most abundant constituents of\n                    <jats:italic>Ac<\/jats:italic>\n                    ESP are homologues of the tissue inhibitors of metalloproteases (TIMP) family. Interestingly, we identified new homologs of well\u2010known vaccine candidates and immunomodulatory proteins. This study provides novel information about the proteins secreted by\n                    <jats:italic>A. caninum<\/jats:italic>\n                    , and constitutes a comprehensive dataset to study the proteins involved in host\u2013hookworm interactions.\n                  <\/jats:p>","DOI":"10.1002\/pmic.201700186","type":"journal-article","created":{"date-parts":[[2017,10,20]],"date-time":"2017-10-20T03:52:37Z","timestamp":1508471557000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Revisiting the\n                    <i>Ancylostoma Caninum<\/i>\n                    Secretome Provides New Information on Hookworm\u2013Host Interactions"],"prefix":"10.1002","volume":"17","author":[{"given":"Taylor","family":"Morante","sequence":"first","affiliation":[{"name":"College of Public Health, Medical &amp; Veterinary Sciences James Cook University  Cairns Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Shepherd","sequence":"additional","affiliation":[{"name":"Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute for Tropical Health and Medicine James Cook University  Cairns Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantin","family":"Constantinoiu","sequence":"additional","affiliation":[{"name":"College of Public Health, Medical &amp; Veterinary Sciences James Cook University  Townsville Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Loukas","sequence":"additional","affiliation":[{"name":"Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute for Tropical Health and Medicine James Cook University  Cairns Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1443-7233","authenticated-orcid":false,"given":"Javier","family":"Sotillo","sequence":"additional","affiliation":[{"name":"Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute for Tropical Health and Medicine James Cook University  Cairns Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI34261"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-7-37"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68653-4"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000086017"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21629"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00563-12"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf8807"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep41883"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M800206-MCP200"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1145"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3109"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn176"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1344"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.772403"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu031"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2002.66.238"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2010.01.003"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-6-156"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2009.02.005"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2011.11.002"},{"key":"e_1_2_5_22_1","doi-asserted-by":"crossref","first-page":"10008","DOI":"10.1016\/S0021-9258(17)36982-X","volume":"269","author":"Moyle M.","year":"1994","journal-title":"J. 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