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Moreover, \u03b2\u2010hairpin is considered as a probable intermediate structure in amyloidogenesis. In this work, a bioinformatics sequence analysis of the known BHR structures is performed in search of amylodogenic motifs able to form \u03b2\u2010arcade fibrils. The analysis shows that the occurrence of the predicted \u03b2\u2010arcade motifs in the BHR regions is very different depending on the BHR structural fold, cellular localization, and phylogeny. One of the most striking observations is the high level of sequence similarity between the BHRs of membranous porins and \u03b2\u2010arcade motifs. This sequence similarity provides additional evidence that the structure of the membranous porins and annular amyloid oligomers may bear a resemblance. Moreover, these results explain how some amyloidogenic sequence can fold in either the ring\u2010like shape oligomers or elongated amyloid fibrils. It has been also found that potentially lethal amyloidogenic \u03b2\u2010arcade motifs are absent in the elongated BHR structures of intracellular eukaryotic proteins. It allows to hypothesize that, in this case, the selective evolutionary pressure acts against aggregation.<\/jats:p>","DOI":"10.1002\/pmic.201800075","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T06:28:02Z","timestamp":1540448882000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Porins and Amyloids are Coded by Similar Sequence Motifs"],"prefix":"10.1002","volume":"19","author":[{"given":"Etienne","family":"Villain","sequence":"first","affiliation":[{"name":"Centre de Recherche en Biologie cellulaire de Montpellier UMR 5237 CNRS Universit\u00e9 Montpellier 1919 Route de Mende CEDEX 5  34293 Montpellier France"},{"name":"Institut de Biologie Computationnelle  34095 Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksei A.","family":"Nikekhin","sequence":"additional","affiliation":[{"name":"Institute of Bioengineering ITMO University  St. Petersburg 197101 Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey V.","family":"Kajava","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Biologie cellulaire de Montpellier UMR 5237 CNRS Universit\u00e9 Montpellier 1919 Route de Mende CEDEX 5  34293 Montpellier France"},{"name":"Institut de Biologie Computationnelle  34095 Montpellier France"},{"name":"Institute of Bioengineering ITMO University  St. Petersburg 197101 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