{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:50:03Z","timestamp":1761648603995,"version":"build-2065373602"},"reference-count":113,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T00:00:00Z","timestamp":1546387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2016A030313396"],"award-info":[{"award-number":["2016A030313396"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteomics"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sprague Dawley rats and Kunming (KM) mice are artificially infected with type II <jats:italic>Toxoplasma gondii<\/jats:italic> strain Prugniaud (Pru) to generate toxoplasmosis, which is a fatal disease mediated by <jats:italic>T. gondii<\/jats:italic> invasion of the central nervous system (CNS) by unknown mechanisms. The aim is to explore the mechanism of differential susceptibility of mice and rats to <jats:italic>T. gondii<\/jats:italic> infection. Therefore, a strategy of isobaric tags for relative and absolute quantitation (iTRAQ) is established to identify differentially expressed proteins (DEPs) in the rats\u2019 and the mice's brains compared to the healthy groups. In KM mice, which is susceptible to <jats:italic>T. gondii<\/jats:italic> infection, complement component 3 (C3) is upregulated and the tight junction (TJ) pathway shows a disorder. It is presumed that <jats:italic>T. gondii<\/jats:italic>\u2010stimulated C3 disrupts the TJ of the blood\u2013brain barrier in the CNS. This effect allows more <jats:italic>T. gondii<\/jats:italic> passing to the brain through the intercellular space.<\/jats:p>","DOI":"10.1002\/pmic.201800271","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T01:23:05Z","timestamp":1543972985000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A Double\u2010Edged Sword: Complement Component 3 in <i>Toxoplasma gondii<\/i> Infection"],"prefix":"10.1002","volume":"19","author":[{"given":"Wan\u2010Yi","family":"Huang","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine South China Agricultural University  Guangzhou 510642 Guangdong P. R. China"},{"name":"Key Laboratory of Zoonosis Prevention and Control of Guangdong Province  Guangzhou 510642 Guangdong P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya\u2010Pei","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine South China Agricultural University  Guangzhou 510642 Guangdong P. R. China"},{"name":"Key Laboratory of Zoonosis Prevention and Control of Guangdong Province  Guangzhou 510642 Guangdong P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasser S.","family":"Mahmmod","sequence":"additional","affiliation":[{"name":"IRTA Centre de Recerca en Sanitat Animal (CReSA, IRTA) Campus de la Universitat Aut\u00f2noma de Barcelona  Cerdanyola del Vall\u00e8s 08193 Barcelona Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona  Cerdanyola del Vall\u00e8s 08193 Barcelona Spain"},{"name":"Infectious Diseases Department of Animal Medicine Faculty of Veterinary Medicine Zagazig University  44511 Zagazig Sharkia Province Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun\u2010Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine South China Agricultural University  Guangzhou 510642 Guangdong P. R. China"},{"name":"Key Laboratory of Zoonosis Prevention and Control of Guangdong Province  Guangzhou 510642 Guangdong P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tang\u2010Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine South China Agricultural University  Guangzhou 510642 Guangdong P. R. China"},{"name":"Key Laboratory of Zoonosis Prevention and Control of Guangdong Province  Guangzhou 510642 Guangdong P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Xiang","family":"Zheng","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine South China Agricultural University  Guangzhou 510642 Guangdong P. R. China"},{"name":"Key Laboratory of Zoonosis Prevention and Control of Guangdong Province  Guangzhou 510642 Guangdong P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine South China Agricultural University  Guangzhou 510642 Guangdong P. R. China"},{"name":"Key Laboratory of Zoonosis Prevention and Control of Guangdong Province  Guangzhou 510642 Guangdong P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu\u2010Xiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Agriculture South China Agricultural University  Guangzhou 510642 Guangdong P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi\u2010Guo","family":"Yuan","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine South China Agricultural University  Guangzhou 510642 Guangdong P. R. China"},{"name":"Key Laboratory of Zoonosis Prevention and Control of Guangdong Province  Guangzhou 510642 Guangdong P. R. China"},{"name":"Key Laboratory of Zoonosis of Ministry of Agriculture and Rural Affairs South China Agricultural University  Guangzhou 510642 Guangdong P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,2]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1079\/AHR2005100"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5274(02)00349-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16412-X"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/15.2.211"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-02-0666"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2016.1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12173"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0147-9571(96)00038-0"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(97)00227-6"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2307\/3285739"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0156255"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2017.06.012"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028925"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00927085"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(85)90442-7"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1322"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2016.11.014"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2017.04.001"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2005.08.001"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601438103"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1203190109"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182013001844"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/172.6.1561"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608310104"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2006.11.012"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2307\/3284205"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(01)00308-3"},{"key":"e_1_2_7_27_1","first-page":"454","volume":"31","author":"Zhou Y. H.","year":"2013","journal-title":"Chin. J. Parasitol. Parasit. Dis."},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-6-96"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.201300044"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr050405o"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1559-0275-11-39"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2016.07.010"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152022"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00985"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2017.03.012"},{"key":"e_1_2_7_35_1","first-page":"1073","volume":"30","author":"Ma S.","year":"2014","journal-title":"Chin. J. Biotechnol."},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2018.1447290"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01016"},{"key":"e_1_2_7_36_3","first-page":"47","volume":"11","author":"Tian D.","year":"2018","journal-title":"Rice (New York, N.Y.)"},{"key":"e_1_2_7_36_4","first-page":"6920213","volume":"2018","author":"Lin X.","year":"2018","journal-title":"Biomed Res. Int."},{"key":"e_1_2_7_36_5","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201800192"},{"key":"e_1_2_7_36_6","doi-asserted-by":"publisher","DOI":"10.1186\/s12953-018-0141-9"},{"key":"e_1_2_7_36_7","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2018.07.059"},{"journal-title":"Gene","year":"2018","author":"Zhou H.","key":"e_1_2_7_36_8"},{"key":"e_1_2_7_36_9","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201800023"},{"journal-title":"Oral Dis.","year":"2018","author":"Shan J.","key":"e_1_2_7_37_1"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19082240"},{"key":"e_1_2_7_37_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2018.07.013"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-018-5954-z"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2015.02.028"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1983.11811741"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1980.11687350"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2000.1182"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbl073"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035516"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023866"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.1976.tb03836.x"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032489"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.074153"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-011-2800-y"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.4303\/jnp\/N100505"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.2307\/3284282"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002990"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/141.3.366"},{"key":"e_1_2_7_49_2","doi-asserted-by":"crossref","first-page":"940","DOI":"10.4049\/jimmunol.142.3.940","volume":"142","author":"Fuhrman S. A.","year":"1989","journal-title":"J. Immunol."},{"key":"e_1_2_7_49_3","doi-asserted-by":"publisher","DOI":"10.1038\/ni1102-1041"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24398"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2014.07.053"},{"key":"e_1_2_7_50_3","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1333-13.2013"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16549"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2016.04.009"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200104053441406"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201591881"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2017.05.025"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06494.x"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0742-0"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2015.02.004"},{"key":"e_1_2_7_58_2","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2008.49.1.1"},{"key":"e_1_2_7_58_3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01491.x"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.10.036"},{"key":"e_1_2_7_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.03.026"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.65.4.446"},{"key":"e_1_2_7_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.04.044"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad8373"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22389"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101157"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-017-8914-1_9"},{"key":"e_1_2_7_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.06.008"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvx077"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1824"},{"key":"e_1_2_7_67_1","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1128\/iai.31.3.1184-1192.1981","volume":"31","author":"Conley F. K.","year":"1981","journal-title":"Infect. Immun."},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00735.x"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81071-5"},{"key":"e_1_2_7_69_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2008.00703.x"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01111-13"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006351"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00272-5"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.158"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.34.20231"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2012.06526.x"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.3.2025"},{"key":"e_1_2_7_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.02.025"},{"key":"e_1_2_7_76_3","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1990.259.4.C577"},{"key":"e_1_2_7_76_4","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2016.70"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4889(98)00125-6"},{"key":"e_1_2_7_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)02004-X"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109254200"},{"key":"e_1_2_7_78_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200206114"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.108.8.2917"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.119"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.09180FP"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2014.01.005"}],"container-title":["PROTEOMICS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpmic.201800271","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pmic.201800271","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pmic.201800271","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pmic.201800271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:55:50Z","timestamp":1761058550000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/pmic.201800271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,2]]},"references-count":113,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1002\/pmic.201800271"],"URL":"https:\/\/doi.org\/10.1002\/pmic.201800271","archive":["Portico"],"relation":{},"ISSN":["1615-9853","1615-9861"],"issn-type":[{"type":"print","value":"1615-9853"},{"type":"electronic","value":"1615-9861"}],"subject":[],"published":{"date-parts":[[2019,1,2]]},"assertion":[{"value":"2018-06-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1800271"}}