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Impairments in reflex cutaneous vasodilation and sweating response can augment the vulnerability of older adults to heat\u2010related injuries following exposure to heat stress. Mechanisms underlying a compromised cutaneous vasodilation are suggested to include reduced sympathetic neural drive, diminished cholinergic co\u2010transmitter contribution, and altered second messenger signaling events. On the other hand, impairments in sweating response are ascribed to reduced sweat gland cholinergic sensitivity and altered cyclooxygenase and nitric oxide signaling. Several practical mitigation strategies such as exercise, passive heating, and behavioral adaptations are proposed as means to overcome heat stress and improve thermal tolerance in the aged. Aerobic exercise training is shown to be amongst the most effective ways to enhance thermoregulatory function. However, in elderly with limited exercise capability due to chronic diseases and mobility issues, passive heating can serve as a functional alternative as it has been shown to confer similar benefits to that of exercise training. Supplementary to exercise training and passive heating, behavioral adaptations can be applied to further enhance the heat\u2010preparedness of the aged.<\/jats:p>","DOI":"10.1002\/pmic.201800468","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T10:09:25Z","timestamp":1571998165000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Thermoregulation in the Aging Population and Practical Strategies to Overcome a Warmer Tomorrow"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9970-6780","authenticated-orcid":false,"given":"Chee Chong Shawn","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Physiology Yong Loo Lin School of Medicine (YLLSoM) National University of Singapore (NUS)  Singapore 117593 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li Kang Karen","family":"Chin","sequence":"additional","affiliation":[{"name":"Department of Physiology Yong Loo Lin School of Medicine (YLLSoM) National University of Singapore (NUS)  Singapore 117593 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2735-395X","authenticated-orcid":false,"given":"Ivan Cherh Chiet","family":"Low","sequence":"additional","affiliation":[{"name":"Department of Physiology Yong Loo Lin School of Medicine (YLLSoM) National University of Singapore (NUS)  Singapore 117593 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,14]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04188"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-006-0089-4"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-3797(99)00025-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00038-009-0112-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-971967"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1969.49.4.671"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00722.2014"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00157.2013"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00123.2014"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083148"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1974.54.1.75"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00298.2010"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01071.2005"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.112508"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00201.2015"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00249.2016"},{"key":"e_1_2_7_15_1","first-page":"1538","volume":"109","author":"Holowatz L. 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