{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:30:36Z","timestamp":1761093036738,"version":"build-2065373602"},"reference-count":7,"publisher":"Wiley","issue":"3-4","license":[{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["306705\/2017\u20106"],"award-info":[{"award-number":["306705\/2017\u20106"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteomics"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Oxidative stress has been long considered an important cause of male infertility, and sperm\u2010derived reactive oxygen species (ROS) have been considered one of the major sources. In article number 1900205, Issue 2, Netherton et\u00a0al. have improved upon current technologies for detection of true ROS\u2010derived oxidative events from those originated by mitochondrial compounds. Moreover, the authors have isolated proteins that bear lipid aldehyde adducts, in order to verify their origin. In their paper, Netherton et al. demonstrate that sperm\u2010derived ROS do not contribute to sperm oxidative stress, which is an important finding, given that most studies consider altered sperm a major source of seminal ROS. Moreover, adducted proteins are mostly of prostatic origin, which leads to questions regarding how and where the oxidative events occur. Under the light of this study and the methodological improvements it has brought, it may be important to revisit some foundation studies in semen and sperm oxidative stress.<\/jats:p>","DOI":"10.1002\/pmic.201900375","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T07:57:16Z","timestamp":1581407836000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mechanisms of Sperm Oxidation: Breaking Down the Origins of Oxidative Activity"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6892-9244","authenticated-orcid":false,"given":"Ricardo P.","family":"Bertolla","sequence":"first","affiliation":[{"name":"Department of Surgery Division of Urology Human Reproduction Section Universidade Federal de S\u00e3o Paulo  S\u00e3o Paulo 04039\u2013060 Brazil"},{"name":"Ricardo Pimenta Bertolla Universidade Federal de S\u00e3o Paulo  R Embau 231 S\u00e3o Paulo SP 04039\u2013060 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,11]]},"reference":[{"key":"e_1_2_3_1_1","doi-asserted-by":"publisher","DOI":"10.7208\/chicago\/9780226458144.001.0001"},{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa003005"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.09.009"},{"volume-title":"WHO Manual for the Standardized Investigation, Diagnosis and Management of the Infertile Male","year":"2000","author":"World Health Organization","key":"e_1_2_3_4_1"},{"key":"e_1_2_3_5_1","first-page":"243","volume":"14","author":"Tremellen K.","year":"2008","journal-title":"Hum. 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