{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:51:41Z","timestamp":1789584701390,"version":"build-2803163510"},"reference-count":66,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T00:00:00Z","timestamp":1606867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201017\u2010CE18\u20100023\u201001"],"award-info":[{"award-number":["ANR\u201017\u2010CE18\u20100023\u201001"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteomics"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Proteomics offers a wide collection of methodologies to study biological systems at the finest granularity. Faced with COVID\u201019, the most worrying pandemic in a century, proteomics researchers have made significant progress in understanding how the causative virus hijacks the host's cellular machinery and multiplies exponentially, how the disease can be diagnosed, and how it develops, as well as its severity predicted. Numerous cellular targets of potential interest for the development of new antiviral drugs have been documented. Here, the most striking results obtained in the proteomics field over this first semester of the pandemic are presented. The molecular machinery of SARS\u2010CoV\u20102 is much more complex than initially believed, as many post\u2010translational modifications can occur, leading to a myriad of proteoforms and a broad heterogeneity of viral particles. The interplay of protein\u2013protein interactions, protein abundances, and post\u2010translational modifications has yet to be fully documented to provide a full picture of this intriguing but lethal biological threat. Proteomics has the potential to provide rapid detection of the SARS\u2010CoV\u20102 virus by mass spectrometry proteotyping, and to further increase the knowledge of severe respiratory syndrome COVID\u201019 and its long\u2010term health consequences.<\/jats:p>","DOI":"10.1002\/pmic.202000198","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T02:10:26Z","timestamp":1606270226000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Proteomics in the COVID\u201019 Battlefield: First Semester Check\u2010Up"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5560-1717","authenticated-orcid":false,"given":"Lucia","family":"Grenga","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay CEA, INRAE, D\u00e9partement M\u00e9dicaments et Technologies pour la Sant\u00e9 (DMTS), SPI  Bagnols\u2010sur\u2010Ceze F\u201030200 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1589-445X","authenticated-orcid":false,"given":"Jean","family":"Armengaud","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay CEA, INRAE, D\u00e9partement M\u00e9dicaments et Technologies pour la Sant\u00e9 (DMTS), SPI  Bagnols\u2010sur\u2010Ceze F\u201030200 France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,2]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2012-7"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2008-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/14789450.2020.1822745"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31211-3"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.02101","volume":"11","author":"Lach\u00e9n\u2010Montes M.","year":"2020","journal-title":"Frontiers in Microbiology"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14789450.2020.1821656"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.0c00380"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30251-8"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9051267"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2020.1791737"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1074\/mcp.RA120.002164","volume":"19","author":"Zecha J.","year":"2020","journal-title":"Mol. 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