{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T15:07:36Z","timestamp":1778425656108,"version":"3.51.4"},"reference-count":82,"publisher":"Wiley","issue":"23-24","license":[{"start":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T00:00:00Z","timestamp":1635120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007793","name":"Stiftelsen Kristian Gerhard Jebsen","doi-asserted-by":"publisher","award":["SKGJ\u2010MED\u2010017"],"award-info":[{"award-number":["SKGJ\u2010MED\u2010017"]}],"id":[{"id":"10.13039\/100007793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteomics"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Celiac disease (CeD) is a prevalent intestinal disorder that only develops in genetically susceptible individuals when they mount a harmful CD4+ T\u2010cell response towards gluten peptides. Intake of gluten leads to inflammation and remodeling of the small intestine with symptoms such as nausea and diarrhea. The only current treatment is a lifelong gluten free diet. The immunological basis for CeD is well characterized but the mechanisms that drive intestinal remodeling are still poorly understood. Transcriptome or proteome analysis of intestinal biopsies gives a global snapshot of all processes that occur in the tissue, including alterations in the epithelial cell layer. This paper will introduce concepts of intestinal remodeling, recapitulate the current understanding of CeD pathogenesis and discuss findings from relevant tissue \u201comics\u201d studies. On the basis of this review, I give perspectives on what tissue \u201comics\u201d studies can tell us about disease pathogenesis with a particular focus on the gluten induced intestinal remodeling.<\/jats:p>","DOI":"10.1002\/pmic.202100057","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T09:17:12Z","timestamp":1633943832000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Insights from tissue \u201comics\u201d analysis on intestinal remodeling in celiac disease"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0257-2112","authenticated-orcid":false,"given":"Jorunn","family":"Stamnaes","sequence":"first","affiliation":[{"name":"Department of Immunology, K.G. Jebsen Coeliac Disease Research Centre University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0021-x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2741\/Karam"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.010908.163145"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0278-0"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114720"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.025528"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037710"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15714-x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15068-4"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI6560"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.26"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16937"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aba8310"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.10.008"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0257-1"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aay8556"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.06.003"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-020-0545-5"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70222-2"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau3429"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201708023"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.08.063"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.12.068"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.07.048"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2018.04.001"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107565"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640619844125"},{"key":"e_1_2_11_29_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.15403\/jgld-3370","article-title":"What is the optimal method assessing for persistent villous atrophy in adult coeliac disease?","volume":"30","author":"Coleman S. H.","year":"2021","journal-title":"Journal of Gastrointestinal and Liver Diseases"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri885"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(94)90047-7"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.11.006"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.41.6.851"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70134-9"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2010.36"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI98819"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaw7756"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608610104"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830230231"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.57"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302196"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1311861110"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70173-9"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.18149"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1620036114"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.12.039"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91819-P"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2656"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201343382"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.646163"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2008.03600.x"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2016.1218540"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.91"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314461"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.10.040"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060028"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)90342-X"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.4.1341"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2003.12.001"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.018374"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.11.014"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2007.03500.x"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2009.00173"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e318217ecec"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2018.03.017"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-018-2898-5"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-019-1089-7"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14369"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-52733-1"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0215132"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2020.07.010"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202003526"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052551"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20200852"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2479"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.03.001"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03852-1"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2020.11.010"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22164-6"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1101\/721258"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0403-9"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.5420"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13858-z"}],"container-title":["PROTEOMICS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pmic.202100057","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pmic.202100057","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pmic.202100057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:02:09Z","timestamp":1761069729000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/pmic.202100057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,25]]},"references-count":82,"journal-issue":{"issue":"23-24","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1002\/pmic.202100057"],"URL":"https:\/\/doi.org\/10.1002\/pmic.202100057","archive":["Portico"],"relation":{},"ISSN":["1615-9853","1615-9861"],"issn-type":[{"value":"1615-9853","type":"print"},{"value":"1615-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,25]]},"assertion":[{"value":"2021-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2100057"}}