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The purpose of this study was to identify proteomic differences and metabolic risk markers in IUGR male and female neonates when compared to appropriate for gestational age (AGA) babies that will provide a better understanding of IUGR pathogenesis and its associated risks. Our results revealed alterations in IUGR cord plasma proteomes with most of the differentially abundant proteins implicated in peroxisome pathways. This effect was evident in females but not in males. Furthermore, we observed that catalase activity, a peroxisomal enzyme, was significantly increased in females (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05) but unchanged in males. Finally, we identified risk proteins associated with obesity, type\u20102 diabetes, and glucose intolerance such as EGF containing fibulin extracellular matrix protein 1 (EFEMP1), proprotein convertase subtilisin\/kexin type 9 (PCSK9) and transforming growth factor beta receptor 3 (TGFBR3) proteins unique to females while coagulation factor IX (C9) and retinol binding protein 4 (RBP4) are unique in males. In conclusion, IUGR may display sexual dimorphism which may be associated with differences in lifelong risk for cardiometabolic disease between males and females.\n                  <\/jats:p>","DOI":"10.1002\/pmic.202300260","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T23:38:02Z","timestamp":1701992282000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Human cord plasma proteomic analysis reveals sexually dimorphic proteins associated with intrauterine growth restriction"],"prefix":"10.1002","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1606-0898","authenticated-orcid":false,"given":"Ayodele Jacob","family":"Akinyemi","sequence":"first","affiliation":[{"name":"Department of Biochemistry Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu 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