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Wastewater treatment plants are known hotspots for the dissemination of antibiotic resistances. Therefore, novel methods for the inactivation of pathogens, and in particular antibiotic\u2010resistant microorganisms (ARM), are of increasing interest. An especially promising method could be a water treatment by physical plasma which provides charged particles, electric fields, UV\u2010radiation, and reactive species. The latter are foremost responsible for the antimicrobial properties of plasma. Thus, with plasma it might be possible to reduce the amount of ARM and to establish this technology as additional treatment stage for wastewater remediation. However, the impact of plasma on microorganisms beyond a mere inactivation was analyzed in more detail by a proteomic approach. Therefore, <jats:italic>Escherichia coli<\/jats:italic> GW\u2010AmxH19, isolated from hospital wastewater in Germany, was used. The bacterial solution was treated by a plasma discharge ignited between each of four pins and the liquid surface. The growth of <jats:italic>E. coli<\/jats:italic> and the pH\u2010value decreased during plasma treatment in comparison with the untreated control. Proteome and antibiotic resistance profile were analyzed. Concentrations of nitrite and nitrate were determined as long\u2010lived indicative products of a transient chemistry associated with reactive nitrogen species (RNS). Conversely, hydrogen peroxide served as indicator for reactive oxygen species (ROS). Proteome analyses revealed an oxidative stress response as a result of plasma\u2010generated RNS and ROS as well as a pH\u2010balancing reaction as key responses to plasma treatment. Both, the generation of reactive species and a decreased pH\u2010value is characteristic for plasma\u2010treated solutions. The plasma\u2010mediated changes of the proteome are discussed also in comparison with the Gram\u2010positive bacterium <jats:italic>Bacillus subtilis<\/jats:italic>. Furthermore, no effect of the plasma treatment, on the antibiotic resistance of <jats:italic>E. coli<\/jats:italic>, was determined under the chosen conditions. The knowledge about the physiological changes of ARM in response to plasma is of fundamental interest to understand the molecular basis for the inactivation. This will be important for the further development and implementation of plasma in wastewater remediation.<\/jats:p>","DOI":"10.1002\/pmic.202300494","type":"journal-article","created":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T22:25:14Z","timestamp":1713738314000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Proteomic profiling of antibiotic\u2010resistant <i>Escherichia coli<\/i> GW\u2010AmxH19 isolated from hospital wastewater treated with physical plasma"],"prefix":"10.1002","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5658-8606","authenticated-orcid":false,"given":"Veronika","family":"Hahn","sequence":"first","affiliation":[{"name":"Leibniz Institute for Plasma Science and Technology (INP)  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Z\u00fchlke","sequence":"additional","affiliation":[{"name":"Institute of Marine 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