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Proteomics analyses of blood, serum, and oral fluids have provided valuable insights into the complex processes occurring in the inflamed periodontium. However, until now, proteome analyses have been primarily limited to small groups of diseased versus healthy individuals. The emergence of population\u2010scale analysis of proteomic data offers opportunities to uncover disease\u2010associated pathways, identify potential drug targets, and discover biomarkers. In this review, we will explore the applications of proteomics in population\u2010based studies and discuss the advancements it brings to our understanding of periodontal inflammation. Additionally, we highlight the challenges posed by currently available data and offer perspectives for future applications in periodontal research. This review aims to explain the ongoing efforts in leveraging proteomics for elucidating the complexities of periodontal diseases and paving the way for clinical strategies.<\/jats:p>","DOI":"10.1002\/pmic.202400055","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T08:28:17Z","timestamp":1735547297000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Population Proteomics: A Tool to Gain Insights Into the Inflamed Periodontium"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5273-7288","authenticated-orcid":false,"given":"Stefan Lars","family":"Reckelkamm","sequence":"first","affiliation":[{"name":"Institute of Health Services Research in Dentistry University of M\u00fcnster  M\u00fcnster Germany"},{"name":"Policlinic for Periodontology and Operative Dentistry University of M\u00fcnster  M\u00fcnster 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