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Using urinary peptidome data from healthy individuals (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a01131) and CKD patients (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a05585) this aspect was investigated in detail. Based on the hypothesis that many collagen peptides are derived not from the full, mature collagen molecule, but from (larger) collagen degradation products, relationships between COL1A1 peptides containing identical sequences were investigated, with the smaller (offspring) peptide being a possible degradation product of the larger (parent) one. The strongest correlations were found for relationships where the parent differed by a maximum of three amino acids from the offspring, indicating an exopeptidase\u2010regulated stepwise degradation process. Regression analysis indicated that CKD affects this degradation process. A comparison of matched CKD patients and control individuals (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0612 each) showed that peptides at the start of the degradation process were consistently downregulated in CKD, indicating an attenuation of COL1A1 endopeptidase\u2010mediated degradation. However, as these peptides undergo further degradation, likely mediated by exopeptidases, this downregulation can become less significant or even reverse, leading to an upregulation of later\u2010stage fragments and potentially explaining the inconsistencies observed in previous studies.\n                  <\/jats:p>","DOI":"10.1002\/pmic.202400279","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T23:49:41Z","timestamp":1735602581000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Investigation of the Urinary Peptidome to Unravel Collagen Degradation in Health and Kidney Disease"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4099-665X","authenticated-orcid":false,"given":"Ioanna K.","family":"Mina","sequence":"first","affiliation":[{"name":"Mosaiques Diagnostics GmbH  Hannover Germany"},{"name":"Institute for Molecular Cardiovascular 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