{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T22:59:00Z","timestamp":1792537140455,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"11-12","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteomics"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>A common hallmark of chronic kidney disease (CKD) is kidney fibrosis, which manifests as an increased deposition and turnover of collagens in the kidneys. Current clinical methods of monitoring disease progression in CKD patients do not truly reflect alterations at the tissue level without the use of invasive biopsies. Naturally occurring urinary peptides associated with kidney function and fibrosis have been previously identified using CE\u2010MS as a non\u2010invasive alternative. Moreover, a specific peptide from collagen type III, a highly abundant interstitial collagen, is the target for the C3M enzyme\u2010linked immunosorbent assay (ELISA)\u2010based assay and has been recorded in the CKD273 urinary biomarker panel measured by CE\u2010MS. We aimed to investigate the intensities of the peptides incorporating the C3M sequence captured by CE\u2010MS in urine of patients with CKD and analyze their association with estimated glomerular filtration rate (eGFR) and kidney interstitial fibrosis and tubular atrophy (IFTA). The investigated collagen type III peptides were reduced in abundance in urine of patients with CKD compared to healthy controls and the peptide intensities were independently correlated to eGFR and inversely correlated with IFTA score. Collectively, this analysis supports that peptides containing the C3M sequence are significantly associated with kidney function decline and tissue fibrosis.<\/jats:p>","DOI":"10.1002\/pmic.202400354","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T01:54:56Z","timestamp":1744336496000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association of Urinary Collagen Type III Degradation Product With Kidney Function and Fibrosis in Chronic Kidney Disease Patients"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0971-913X","authenticated-orcid":false,"given":"Emily M.","family":"Martin","sequence":"first","affiliation":[{"name":"Nordic Bioscience A\/S  Herlev Denmark"},{"name":"University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Genovese","sequence":"additional","affiliation":[{"name":"Nordic Bioscience A\/S  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Mischak","sequence":"additional","affiliation":[{"name":"Mosaiques Diagnostics GmbH  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1407-2534","authenticated-orcid":false,"given":"Justyna","family":"Siwy","sequence":"additional","affiliation":[{"name":"Mosaiques Diagnostics GmbH  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Rupprecht","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Angiology and Rheumatology Klinikum Bayreuth GmbH  Bayreuth Germany"},{"name":"Department of Nephrology Medizincampus Oberfranken Friedrich\u2010Alexander\u2010University Erlangen\u2010N\u00fcrnberg  Erlangen Germany"},{"name":"Kuratorium for Dialysis and Transplantation (KfH), Bayreuth  Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Catanese","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Angiology and Rheumatology Klinikum Bayreuth GmbH  Bayreuth Germany"},{"name":"Department of Nephrology Medizincampus Oberfranken Friedrich\u2010Alexander\u2010University Erlangen\u2010N\u00fcrnberg  Erlangen Germany"},{"name":"Kuratorium for Dialysis and Transplantation (KfH), Bayreuth  Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8917-2412","authenticated-orcid":false,"given":"Agnieszka","family":"Latosinska","sequence":"additional","affiliation":[{"name":"Mosaiques Diagnostics GmbH  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"issue":"4","key":"e_1_2_9_1_1","first-page":"167","article-title":"Correlations Between Renal Cortical Interstitial Fibrosis, Atrophy of the Proximal Tubules and Impairment of the Glomerular Filtration Rate","volume":"15","author":"Mackensen\u2010Haen S.","year":"1981","journal-title":"Clinical Nephrology"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755\u20101536\u20107\u20104"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24119156"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201017083\u2010w"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1993.312"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/12.9.1883"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108525"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201051905\u20103"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2010.03.012"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfz174"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13071093"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18\u20102599"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0001132021"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv301"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0283296"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062837"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M110.001917"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23654"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014050423"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12\u20100348"},{"key":"e_1_2_9_21_1","doi-asserted-by":"crossref","unstructured":"I. 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F.Iglesias\u2010Martinez M.Ley et\u00a0al. \u201cInvestigation of the Urinary Peptidome to Unravel Collagen Degradation in Health and Kidney Disease \u201d Proteomics 30 e202400279\u00a0(2024) https:\/\/doi.org\/10.1101\/2024.09.30.24314592.","DOI":"10.1101\/2024.09.30.24314592"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/proteomes9030032"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.201900091"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr800401m"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv063"}],"container-title":["PROTEOMICS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pmic.202400354","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:39:29Z","timestamp":1761057569000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/pmic.202400354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,10]]},"references-count":25,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/pmic.202400354"],"URL":"https:\/\/doi.org\/10.1002\/pmic.202400354","archive":["Portico"],"relation":{},"ISSN":["1615-9853","1615-9861"],"issn-type":[{"value":"1615-9853","type":"print"},{"value":"1615-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,10]]},"assertion":[{"value":"2024-11-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202400354"}}