{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T20:28:03Z","timestamp":1783024083324,"version":"3.54.6"},"reference-count":106,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201017\u2010CE12\u20108160004\u201001"],"award-info":[{"award-number":["ANR\u201017\u2010CE12\u20108160004\u201001"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201021\u2010CE44\u20100035"],"award-info":[{"award-number":["ANR\u201021\u2010CE44\u20100035"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["SPF202309017479"],"award-info":[{"award-number":["SPF202309017479"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/00936"],"award-info":[{"award-number":["PI20\/00936"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FI17\/00224"],"award-info":[{"award-number":["FI17\/00224"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["MV20\/00026"],"award-info":[{"award-number":["MV20\/00026"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteomics"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Protein phosphorylation regulates key events of male germ cell differentiation. In the testis, SRPK1 and PP1\u03b3 are involved in protamine phosphorylation and dephosphorylation, respectively, and their deregulation is linked to defective chromatin structure and male infertility. The aim of this study was to expand our knowledge on the molecular role of these phosphorylation\u2010modulating proteins through the identification of novel partners in the testis, potentially supporting additional roles in sperm development. Using immunoprecipitation followed by LC\u2010MS\/MS, we identified yet undescribed interactions of SRPK1 and PP1\u03b3 with proteins involved in sperm formation and regulation of spermatogenic gene expression. We reported that SRPK1 interacts with the key splicing regulator ASF\/SF2, as well as with other proteins involved in posttranscriptional regulation such as PABP1 or IGF2BP3. We showed that the testis\u2010enriched isoform 2 of PP1\u03b3 (PP1\u03b32) interacts with PIHI1D1, part of the R2TP chaperone complex, and predicted that ZFR, NDUFB10 and ILF2 interactions with PP1\u03b32 happen within the C\u2010terminal sequence which is specific of PP1\u03b32 proteoform. Both SRPK1 and PP1\u03b3 interactomes include ILF2 and TBLX1R1, with roles in gene expression regulation. Most of the identified proteins are known phosphoproteins in male germ cells, supporting a functional interaction. Overall, our results suggest additional roles for SRPK1 and PP1\u03b3 during spermatogenesis, shedding light into the orchestrated regulation of the complex mechanisms driving sperm formation. Data are available via ProteomeXchange with identifiers PXD054959 and PXD054960.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance of the Study<\/jats:title>\n                    <jats:p>In the present work, we report the first testicular protein interactome of two broad phosphorylation\u2010modulating proteins, the kinase SRPK1 and the phosphatase PP1\u03b3, known to be essential regulators of chromatin remodeling during male germ cell development. Our novel protein\u2010protein interactions reveal additional roles for SRPK1 and PP1\u03b3 in male germ cells, in key processes including splicing, gene expression, protein homeostasis, or formation of sperm\u2010specific structures. Our data will therefore contribute to a better understanding of the complex and orchestrated molecular mechanisms controlling testicular activity and proper sperm formation.<\/jats:p>\n                    <jats:p>The lack of male germ cell\u2010specific protein\u2013protein interaction datasets currently challenges the research on the still largely unknown molecular mechanisms driving male germ cell differentiation. This jeopardizes exploratory approaches and in silico validations in a testis\u2010specific manner, as most available datasets have been obtained in somatic cells. Thus, our protein\u2010protein interaction data will be a useful resource to those interested in identifying the origins of male reproductive health problems related to protein phosphorylation. Furthermore, our analyses suggesting that some of these interactions may also occur in other organs\u00a0extend the relevance of our findings to the broader scientific community.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pmic.70121","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T06:02:02Z","timestamp":1774936922000},"page":"42-56","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multiple Roles of Protamine Kinase SRPK1 and Phosphatase PP1\u03b3 in Sperm Development"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3475-2086","authenticated-orcid":false,"given":"Alberto","family":"de la Iglesia","sequence":"first","affiliation":[{"name":"Molecular Biology of Reproduction and Development Research Group Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Fundaci\u00f3 de Recerca Cl\u00ednic Barcelona (FRCB) Facultat de Medicina i Ci\u00e8ncies de la Salut Universitat de Barcelona (UB)  Barcelona Spain"},{"name":"Institut Cochin INSERM CNRS Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5057-4334","authenticated-orcid":false,"given":"M\u00e9lina","family":"Blanco","sequence":"additional","affiliation":[{"name":"Institut Cochin INSERM CNRS Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9 et Universit\u00e9 Paris\u2010Saclay, iRCM\/IBJF CEA, UMR Stabilit\u00e9 G\u00e9n\u00e9tique Cellules Souches et Radiations Laboratoire des Cellules Souches Germinales  Fontenay\u2010aux\u2010RosesParis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3272-0163","authenticated-orcid":false,"given":"Meritxell","family":"Jodar","sequence":"additional","affiliation":[{"name":"Molecular Biology of Reproduction and Development Research Group Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Fundaci\u00f3 de Recerca Cl\u00ednic Barcelona (FRCB) Facultat de Medicina i Ci\u00e8ncies de la Salut Universitat de Barcelona (UB)  Barcelona Spain"},{"name":"Biochemistry and Molecular Genetics Service Hospital Cl\u00ednic Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9621-836X","authenticated-orcid":false,"given":"Olivier","family":"Feudjio","sequence":"additional","affiliation":[{"name":"Institut Cochin INSERM CNRS Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"ADLIN Science  \u00c9vry\u2010Courcouronnes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4049-3976","authenticated-orcid":false,"given":"Marjorie","family":"Leduc","sequence":"additional","affiliation":[{"name":"Proteom'IC facility Institut Cochin CNRS INSERM Universit\u00e9 Paris Cit\u00e9  PARIS France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9407-2675","authenticated-orcid":false,"given":"Judit","family":"Castillo","sequence":"additional","affiliation":[{"name":"Molecular Biology of Reproduction and Development Research Group Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Fundaci\u00f3 de Recerca Cl\u00ednic Barcelona (FRCB) Facultat de Medicina i Ci\u00e8ncies de la Salut Universitat de Barcelona (UB)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6275-5412","authenticated-orcid":false,"given":"Julie","family":"Cocquet","sequence":"additional","affiliation":[{"name":"Institut Cochin INSERM CNRS Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4876-2410","authenticated-orcid":false,"given":"Rafael","family":"Oliva","sequence":"additional","affiliation":[{"name":"Molecular Biology of Reproduction and Development Research Group Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Fundaci\u00f3 de Recerca Cl\u00ednic Barcelona (FRCB) Facultat de Medicina i Ci\u00e8ncies de la Salut Universitat de Barcelona (UB)  Barcelona Spain"},{"name":"Biochemistry and Molecular Genetics Service Hospital Cl\u00ednic Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.05.031"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioac065"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.9b00351"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/19396368.2012.691943"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00013.2015"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12461"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.4172\/2161\u2010038X.S1\u2010005"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.RA118.001278"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2025.195132"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0502\u2010e127"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874467208666150126154222"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dml009"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/wsbm.1588"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/proteomes9020021"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756\u20108935\u20107\u20102"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.9b00499"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/4.1.149"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/4.1.163"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.020"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/27.14.2972"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M311949200"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu073"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aao7232"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euprot.2013.11.009"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.113.110239"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod54.3.709"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP\u201009\u20100314"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/369678a0"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.3.334"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M308854200"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2011.10.010"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4846"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/150514"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742\u20104658.2010.07987.x"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033\u2010018\u20104545\u20105"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M305764200"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.03.023"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.06.020"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611696104"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968\u20100004(97)01060\u20108"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2014.07.001"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abh2169"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz047"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2018.07.025"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202256316"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010024\u201007393\u2010x"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471250953.bi1114s51"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae1071"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102105\u201012\u2010323"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz247"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2017.32"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.8b00235"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M113.031591"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3901"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/75556"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1108"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1074"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1101\/2024.10.23.619601"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201007487\u2010w"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae1010"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adj8172"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201900055"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M114.039073"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1267"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M114.045468"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmy017"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12859\u2010015\u20100611\u20103"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1054"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010014\u20100560\u20106"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109915"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmaf023"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.11.022"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201050052\u2010z"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.34422"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.113.116111"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.83474"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2007.08.029"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44318\u2010025\u201000659\u2010y"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2010.07.008"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104755200"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.197558"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.24272\/j.issn.2095\u20108137.2023.388"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01029\u201007"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M112.020339"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1101\/2024.10.16.618660"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2011.08.016"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378\u20101119(98)00615\u20105"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201003326\u20105"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2012.01.014"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2004.12.030"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2221762120"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP\u201013\u20100224"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2019.04.015"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00450.2019"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201083424\u20101"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioaa134"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.13431"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1814809"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201089334\u2010w"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioy225"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1997.4907"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004861"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi3010158"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2011.02.018"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.103.026880"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab1038"}],"container-title":["PROTEOMICS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pmic.70121","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pmic.70121","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pmic.70121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T20:00:40Z","timestamp":1783022440000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/pmic.70121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,30]]},"references-count":106,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/pmic.70121"],"URL":"https:\/\/doi.org\/10.1002\/pmic.70121","archive":["Portico"],"relation":{},"ISSN":["1615-9853","1615-9861"],"issn-type":[{"value":"1615-9853","type":"print"},{"value":"1615-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,30]]},"assertion":[{"value":"2025-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}