{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T07:17:29Z","timestamp":1787815049795,"version":"build-2784847793"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteomics"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Multiple myeloma (MM) evolves from monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma\u00a0(SMM) with annual progression rates of 1% and 10%, respectively. Current risk models don't fully capture the underlying dynamic molecular processes. We hypothesized that urinary peptides reflect disease\u2010specific microenvironmental alterations in plasma cell dyscrasias. To test this hypothesis, capillary electrophoresis coupled to mass spectrometry (CE\u2013MS) was applied to profile the urinary peptidome of 314 individuals, including a discovery group (42 MGUS, 27 SMM, 14\u00a0MM), an independent validation group (45 MGUS, 9 SMM, 7\u00a0MM, 9 with plasmacytoma), 86 without underlying malignancy, and 75 patients with impaired kidney function. One hundred twenty\u2010one peptides were significantly altered between MM and MGUS and displayed a monotonic abundance trend across the MGUS\u2013SMM\u2013MM continuum. These peptides predominantly derived from collagens, beta\u20102 microglobulin, alpha\u20101 antitrypsin, and antithrombin\u2010III. Integration of these 121 peptides into a support vector machine classifier achieved an area under the curve of 0.94 (0.85\u20130.99; 95% CI) in the independent validation cohort, with 100% sensitivity and 82% specificity for MM detection. The finding that urinary peptides enable non\u2010invasive molecular discrimination of MM from precursor states represents a solid basis for a prospective evaluation in prognosis and detection of progression.<\/jats:p>","DOI":"10.1002\/pmic.70143","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T06:27:28Z","timestamp":1779258448000},"page":"82-94","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Peptidomic Profiling Reveals Extracellular Matrix Remodeling Signatures Discriminative of Multiple Myeloma"],"prefix":"10.1002","volume":"26","author":[{"given":"Maria","family":"Frantzi","sequence":"first","affiliation":[{"name":"Department of Biomarker Research Mosaiques Diagnostics GmbH  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melika","family":"Ahangar","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics National Institute of Genetic Engineering and Biotechnology (NIGEB)  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Vlahou","sequence":"additional","affiliation":[{"name":"Center of Systems Biology Biomedical Research Foundation of the Academy of Athens (BRFAA) Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Mischak","sequence":"additional","affiliation":[{"name":"Department of Biomarker Research Mosaiques Diagnostics GmbH  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Solia","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics School of Medicine National and Kapodistrian University of Athens (NKUA)  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Foteini","family":"Theodorakakou","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics School of Medicine National and Kapodistrian University of Athens (NKUA)  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine Ivy","family":"Liacos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics School of Medicine National and Kapodistrian University of Athens (NKUA)  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Zoidakis","sequence":"additional","affiliation":[{"name":"Department of Biology National and Kapodistrian University of Athens (NKUA)  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Terpos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics School of Medicine National and Kapodistrian University of Athens (NKUA)  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meletios A.","family":"Dimopoulos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics School of Medicine National and Kapodistrian University of Athens (NKUA)  Athens Greece"},{"name":"Department of Medicine Korea University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efstathios","family":"Kastritis","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics School of Medicine National and Kapodistrian University of Athens (NKUA)  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2023.103920"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25791"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.4084\/MJHID.2024.062"},{"key":"e_1_2_10_5_1","first-page":"241","volume-title":"Long\u2010Term Follow\u2010Up of Monoclonal Gammopathy of Undetermined Significance","author":"Kyle R. 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