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The BraI\/R QS system is conserved among\n                    <jats:italic>Burkholderia<\/jats:italic>\n                    and\n                    <jats:italic>Paraburkholderia<\/jats:italic>\n                    species, and its regulatory role is still unknown. In this study, the BraI\/R QS of\n                    <jats:italic>P. kururiensis<\/jats:italic>\n                    was investigated for biological control of another bacterial species. The results demonstrate that the functional BraI\/R system influences interbacterial competition, as\n                    <jats:italic>braI<\/jats:italic>\n                    and\n                    <jats:italic>braR<\/jats:italic>\n                    mutant strains failed to inhibit the growth of\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    , in contrast to the wild\u2010type strain. These findings suggest that the BraI\/R QS system plays a regulatory role in modulating interspecies antagonism. Comparative exoproteome analyses were performed for the wild\u2010type and the BraI\/R QS\u2010mutant\n                    <jats:italic>P. kururiensis<\/jats:italic>\n                    strains, revealing distinct protein populations, including structural and effector proteins of the Type VI secretion system (T6SS). Genomic mapping revealed that two of those T6SS\u2010proteins were encoded within a specific T6SS gene cluster (T6SS\u20103), while others originate outside any major T6SS gene cluster. The identification of exoproteome targets regulated by the BraI\/R QS system represents a significant advance toward the understanding of the molecular mechanisms underpinning\n                    <jats:italic>P. kururiensis<\/jats:italic>\n                    interactions with competing bacteria, further supporting its potential as a biological control agent against phytopathogenic and\/or free\u2010living species.\n                  <\/jats:p>","DOI":"10.1002\/pmic.70163","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T07:24:54Z","timestamp":1783495494000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exoproteome Remodeling by the BraI\/R Quorum Sensing Circuit and Interspecies Competition in\n                    <i>Paraburkholderia<\/i>"],"prefix":"10.1002","author":[{"given":"Gabrielle Tom\u00e9","family":"Cordeiro","sequence":"first","affiliation":[{"name":"Instituto de Qu\u00edmica Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6040-3138","authenticated-orcid":false,"given":"Yara Martins","family":"da Silva","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna Fernandes","family":"Lessa","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Code\u00e7o Ferreira","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadassa Loth","family":"de Oiveira","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5507-7142","authenticated-orcid":false,"given":"F\u00e1bio C\u00e9sar Sousa","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6985-8828","authenticated-orcid":false,"given":"Bianca Cruz","family":"Neves","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2014.00429"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.02093"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11274\u2010025\u201004256\u20103"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.59436\/jsianev4i2\/270"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mbo3.801"},{"issue":"116","key":"e_1_2_9_7_1","article-title":"Burkhoderia brasilensis sp. nov., uma Esp\u00e9cie de bact\u00e9ria diazotr\u00f3fica endof\u00edtica","volume":"69","author":"Baldani V.","year":"1997","journal-title":"Anais Da Academia Brasileira de Ciencias"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI\u201007\u201014\u20100225\u2010R"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201037314\u20107"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","unstructured":"K. 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