{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:47:09Z","timestamp":1784180829143,"version":"3.55.0"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T00:00:00Z","timestamp":1557100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PM&amp;R"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Because of discrepant published results, there is a need to systematically analyze the literature that has evaluated the effectiveness of harmonic whole\u2010body vibration (WBV) and randomized WBV in patients with Parkinson disease (PD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effectiveness of harmonic versus randomized WBV on motor symptoms, balance, gait, and mobility in people with PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Type<\/jats:title><jats:p>Meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Literature Survey<\/jats:title><jats:p>Established databases PubMed, EMBASE, CINAHL, Cochrane, Trip, and PEDro; library of the Saarland University; and electronic library of journals, including publications from 1960 to November 2017, were scanned by using \u201cParkinson\u201d and \u201cvibration\u201d as combined search terms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>First, data were extracted from the full\u2010text version, including number of participants, severity of disease, medication status, study design, use of vibration treatment, duration of study, number of treatment sessions and trials per session, vibration frequency and amplitude, duration of trials and rest periods, and pre\u2010 and posttest data. Qualitative analysis was performed by using the PEDro score. Standardized mean differences (SMD) with 95% confidence intervals (CI) were used to verify the efficacy of harmonic versus randomized WBV on mobility, balance, gait, and motor symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Synthesis<\/jats:title><jats:p>From 244 publications found in online databases, 17 eligible studies fulfilled eligibility criteria and were further analyzed qualitatively. Out of those, 7 studies attained moderate to high quality (mean PEDro score 4.6 points, SD 2.9) and were then further analyzed quantitatively. A large variation, between no effects (SMD\u2009=\u20090.06, 95% CI\u2009=\u2009\u22120.78 to 0.90) and weak effects (SMD\u2009=\u20090.46, 95% CI\u2009=\u2009\u22120.51 to 1.43), was found for motor symptoms, balance, gait, and mobility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is no clear evidence of a PD symptom\u2010reducing effect (motor symptoms, balance, gait, and mobility) of WBV compared with respective control conditions. Only a few studies found significant group differences for mobility and motor symptoms. Therefore, the overall effects of vibration therapy on PD remain somewhat inconsistent. Further high\u2010quality studies should determine the efficacy of harmonic versus randomized WBV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>II<\/jats:p><\/jats:sec>","DOI":"10.1002\/pmrj.12094","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T21:52:52Z","timestamp":1548712372000},"page":"640-653","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Analysis of the Effects of Whole\u2010Body Vibration in Parkinson Disease \u2013 Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"11","author":[{"given":"Andrea","family":"Dincher","sequence":"first","affiliation":[{"name":"Sportwissenschaftliches Institut der Universit\u00e4t des Saarlandes (Institute of Sports Sciences of Saarland University)  Saarbr\u00fccken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Sportwissenschaftliches Institut der Universit\u00e4t des Saarlandes (Institute of Sports Sciences of Saarland University)  Saarbr\u00fccken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Wydra","sequence":"additional","affiliation":[{"name":"Sportwissenschaftliches Institut der Universit\u00e4t des Saarlandes (Institute of Sports Sciences of Saarland University)  Saarbr\u00fccken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207454.2011.620197"},{"key":"e_1_2_6_3_1","volume-title":"Neuroanatomie","author":"Trepel M","year":"2008"},{"key":"e_1_2_6_4_1","first-page":"1","article-title":"Postural stability in Parkinson's disease patients is improved after stochastic resonance therapy","volume":"4","author":"Kaut O","year":"2016","journal-title":"Parkinsons Dis"},{"issue":"5","key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.33549\/physiolres.932743","article-title":"Protection of dopamine neurons by vibration training and up\u2010regulation of brain\u2010derived neurotrophic factor in a MPTP mouse model of Parkinson's disease","volume":"63","author":"Zhao L","year":"2014","journal-title":"Physiol Res"},{"issue":"2","key":"e_1_2_6_6_1","first-page":"63","article-title":"Whole\u2010body vibration effects in patients affected with Parkinson's disease: a systematic literature review","volume":"4","author":"Pozo\u2010Cruz B","year":"2011","journal-title":"Rev Andal Med Deport"},{"key":"e_1_2_6_7_1","first-page":"63","article-title":"Physiotherapy versus placebo or no intervention in Parkinson's disease (Review)","volume":"9","author":"Tomlinson CL","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"issue":"5","key":"e_1_2_6_8_1","first-page":"8","article-title":"Role of the whole body vibration machine in the prevention and management of osteoporosis in old age: a systematic review","volume":"23","author":"Swe M","year":"2016","journal-title":"Malays J Med Sci"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1268010"},{"issue":"7","key":"e_1_2_6_10_1","first-page":"728","article-title":"Vibrationstraining, biomechanische stimulation und stochastische resonanz therapie","volume":"60","author":"Haas CT","year":"2008","journal-title":"Zeitsch Physiother"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1013-7025(09)70005-3"},{"key":"e_1_2_6_12_1","first-page":"44","article-title":"Tonic vibratory reflex. 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