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Although physical function improves with rehabilitation after dysvascular LLA, physical activity remains largely unchanged, and factors contributing to limited daily step count are unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify factors that contribute to daily step count after dysvascular LLA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cross\u2010sectional, secondary data analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Outpatient rehabilitation facilities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010eight patients with dysvascular major LLA (age: 64\u2009\u00b1\u20099 years, body mass index: 30\u2009\u00b1\u20098 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , male: 95%, transtibial LLA: 95%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were collected by a blinded assessor after dysvascular LLA. Candidate explanatory variables included (1) demographics, (2) LLA characteristics, (3) comorbidities and health behaviors, and (4) physical function. Variables with univariate associations with log steps\/day (transformed due to non\u2010normality) were included in a multiple linear regression model using backward elimination to identify factors that explained significant variability in log steps\/day.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary Outcome Measure<\/jats:title>\n                    <jats:p>The primary outcome, daily step count, was measured with accelerometer\u2010based activity monitors worn by participants for 10 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants took an average (\u00b1 SD) of 1450 \u00b1\u20091309 steps\/day. After backward elimination, the final model included four variables explaining 62% of the overall daily step count (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.0001): 2\u2010minute walk distance (32%), assistive device use (11%), cardiovascular disease (10%), and pre\u2010amputation walking time (11%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Average daily step count of 1450 steps\/day reflects the lowest category of sedentary behavior. Physical function, cardiovascular disease, and pre\u2010amputation walking time explain 62% of daily step count after dysvascular LLA. Although physical rehabilitation commonly focuses on improving physical function, interventions to increase daily step count after dysvascular LLA should also consider chronic disease and health behaviors that predate LLA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>III.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pmrj.12121","type":"journal-article","created":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T21:30:21Z","timestamp":1549488621000},"page":"1050-1058","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Physical Function and Pre\u2010Amputation Characteristics Explain Daily Step Count after Dysvascular Amputation"],"prefix":"10.1002","volume":"11","author":[{"given":"Matthew J.","family":"Miller","sequence":"first","affiliation":[{"name":"Physical Therapy Program, 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