{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:37:30Z","timestamp":1788820650294,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T00:00:00Z","timestamp":1568764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PM&amp;R"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>There exists a dearth of evidence on rehabilitation factors that influence prosthetic mobility in people with lower limb amputation (LLA). Examining variables that contribute to prosthetic mobility can inform rehabilitation interventions, providing guidance in developing more comprehensive care for these individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the influence of modifiable and non\u2010modifiable variables related to LLA and their impact on prosthetic mobility, using the International Classification of Functioning, Disability and Health (ICF) model. Secondarily, to determine if personal factors and self\u2010reported balance and mobility are predictive of Component timed\u2010up\u2010and\u2010go (cTUG) performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cross\u2010sectional study of a convenience sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>National conference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>People (N=68) with non\u2010vascular causes of unilateral LLA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Assessment of anthropometrics, mobility, bilateral hip extensor strength, hip range of motion, single limb balance, and self report measures. Lasso linear regression and extreme gradient boosting analyses were used to determine influence of variables on prosthetic mobility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measure<\/jats:title><jats:p>Timed performance of the cTUG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The following five variables were found to influence basic prosthetic mobility (<jats:italic>P<\/jats:italic>\u200a\u2264\u200a.05) in people with transtibial amputation: hip extensor strength, hip range of motion, single limb balance, waist circumference, and age. In the transfemoral cohort, number of comorbidities and waist circumference primarily influenced prosthetic mobility. Additionally, 66% of the variance in cTUG total time for the entire sample could be explained by simply regressing on level of amputation, number of comorbidities, age and Activities\u2010specific Balance Confidence scale score, all variables easily collected in a waiting room.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Variables that are modifiable with physical therapy intervention including hip extensor strength, hip range of motion, single limb balance, and waist circumference significantly influenced basic prosthetic mobility. These variables can be affected by targeted rehabilitation interventions and lifestyle changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>II.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pmrj.12223","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T15:29:31Z","timestamp":1563809371000},"page":"130-139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Variables that Influence Basic Prosthetic Mobility in People With Non\u2010Vascular Lower Limb Amputation"],"prefix":"10.1002","volume":"12","author":[{"given":"Robert","family":"Gailey","sequence":"first","affiliation":[{"name":"Department of Physical Therapy Miller School of Medicine, University of Miami Coral Gables FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7959-2496","authenticated-orcid":false,"given":"Sheila","family":"Clemens","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Miller School of Medicine, University of Miami Coral Gables FL"},{"name":"Physical Therapy Department Nicole Wertheim College of Nursing and Health Professions, Florida International University, FL Research Department, Miami Veterans Administration Healthcare System Miami FL"},{"name":"Research Department Miami Veterans Administration Healthcare System Miami FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Sorensen","sequence":"additional","affiliation":[{"name":"The Henry M. Jackson Foundation for the Advancement of Military Medicine Bethesda MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neva","family":"Kirk\u2010Sanchez","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Miller School of Medicine, University of Miami Coral Gables FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Gaunaurd","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Miller School of Medicine, University of Miami Coral Gables FL"},{"name":"Research Department Miami Veterans Administration Healthcare System Miami FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Raya","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Miller School of Medicine, University of Miami Coral Gables FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn","family":"Klute","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering University of Washington Seattle WA"},{"name":"Rehabilitation Research and Development VA Puget Sound Health Care System Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Pasquina","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Uniformed Services University of the Health Sciences Bethesda MD"},{"name":"Department of Rehabilitation Walter Reed National Military Medical Center Bethesda MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200708000-00003"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2007.11.005"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2013.10.032"},{"key":"e_1_2_6_5_1","first-page":"276","article-title":"Changes in hip muscles after above\u2010knee amputation","volume":"319","author":"Jaegers SM","year":"1995","journal-title":"Clin Orthop Relat Res."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(96)90151-3"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269215506070700"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2017.10.051"},{"key":"e_1_2_6_9_1","volume-title":"Disability, and Health: ICF","author":"International Classification of Functioning","year":"2001"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/85.7.626"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(99)90234-4"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1991.tb01616.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269215517728324"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/03093640903585008"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/03093649409164400"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(02)04952-3"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.2340\/16501977-0393"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1682\/JRRD.2013.02.0035"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0309364611407676"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2016.02.024"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002060-199601000-00004"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-013-0618-z"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2016.07.026"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.2340\/16501977-2042"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(02)04807-4"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2018.05.016"},{"issue":"3","key":"e_1_2_6_28_1","first-page":"305","article-title":"Permutation and bootstrap Kolmogorov\u2010Smirnov tests for the equality of two distributions","volume":"22","author":"Praestgaard JT","year":"1995","journal-title":"Scand J Stat."},{"key":"e_1_2_6_29_1","volume-title":"Multiple regression: Testing and interpreting interactions","author":"Aiken LS","year":"1991"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-84858-7"},{"key":"e_1_2_6_31_1","doi-asserted-by":"crossref","unstructured":"FriedmanJ HastieT TibshiraniR. glmnet: Lasso and elastic\u2010net regularized generalized linear models. 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