{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T06:23:30Z","timestamp":1772778210380,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T00:00:00Z","timestamp":1574812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PM&amp;R"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Low cardiorespiratory fitness (CRF) is a predictor of stroke risk and poor outcome poststroke. Fitness levels are rarely assessed in the acute phase and it is unclear if it is safe for stroke survivors and people with transient ischemic attack (TIA) to perform a graded exercise test to assess fitness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine if people within 14\u2009days post stroke can safely perform a graded exercise test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Research institute.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>People with stroke or TIA admitted to an acute stroke unit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Intervention<\/jats:title><jats:p>Not applicable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Safety of performing a graded exercise test early post stroke. Safety outcomes were (1) occurrence of an adverse event or (2) &lt;85% blood oxygen saturation (SpO<jats:sub>2<\/jats:sub>). Participants performed a graded exercise test on a recumbent stepper at a research institute &lt;2\u2009weeks postevent. CRF was determined by measuring peak volume of oxygen uptake (VO<jats:sub>2peak<\/jats:sub>) using a metabolic cart.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010nine participants were enrolled in the study (median age 69\u2009years; interquartile range 58\u201075). Sixteen were diagnosed with TIA and 13 with a mild stroke. Twenty\u2010eight participants completed the test; one participant was unable to perform the test due to back pain. The test was terminated due to standardized stopping criteria in 26 cases (5\u2009=\u2009volitional fatigue, 6\u2009=\u2009unable to keep required cadence, 15\u2009=\u2009reaching 85% HR<jats:sub>max<\/jats:sub>), one due to safety (ie, SpO<jats:sub>2<\/jats:sub>\u2009&lt;\u200985%), and one was inadvertently terminated before stopping criteria were reached. Average CRF determined by the exercise test was low; mean VO<jats:sub>2peak<\/jats:sub> of 16.2\u2009\u00b1\u20094.5 mL\/kg\/min for men (n\u2009=\u200920) and 12.4\u2009\u00b1\u20093.6 mL\/kg\/min for women (n\u2009=\u20098).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Determining exercise capacity early post stroke and TIA using a graded exercise test appears to be safe in patients with mild deficits. This information should be useful to plan tailored exercise programs. Further research should focus on determining safety of exercise testing in more severely affected stroke survivors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pmrj.12259","type":"journal-article","created":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T20:02:02Z","timestamp":1570737722000},"page":"445-453","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Safety of Performing a Graded Exercise Test Early after Stroke and Transient Ischemic Attack"],"prefix":"10.1002","volume":"12","author":[{"given":"Liam","family":"Johnson","sequence":"first","affiliation":[{"name":"Stroke Theme, Florey Institute of Neuroscience and Mental Health, University of Melbourne  Heidelberg Australia"},{"name":"NHMRC Centre of Research Excellence in Stroke Rehabilitation and Brain Recovery  Melbourne Australia"},{"name":"School of Health Sciences Australian Catholic University  Melbourne 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