{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T15:44:54Z","timestamp":1765295094712,"version":"3.40.5"},"reference-count":56,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T00:00:00Z","timestamp":1582588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008460","name":"National Center for Complementary and Integrative Health","doi-asserted-by":"publisher","award":["1 F32 AT009272\u201001"],"award-info":[{"award-number":["1 F32 AT009272\u201001"]}],"id":[{"id":"10.13039\/100008460","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["5 R01 AG032052\u201003"],"award-info":[{"award-number":["5 R01 AG032052\u201003"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PM&amp;R"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Clarifying the relationship between pain phenotypes and physical function in older adults may enhance screening and treatment for functional decline in primary care settings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the association of more severe pain phenotypes with neuromuscular impairments or mobility limitations among older community\u2010dwelling primary care patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cross\u2010sectional analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>The Boston Rehabilitative Impairment Study of the Elderly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Adults aged 65 years or older.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We counted the number of musculoskeletal pain locations (none, single site, multisite, or widespread) using the McGill Pain Questionnaire and identified pain intensity tertiles using the Brief Pain Inventory. Neuromuscular attributes (trunk extensor muscle endurance, and leg speed, strength, strength asymmetry, and range of motion) and mobility (Short Physical Performance Battery [SPPB]) were assessed with performance\u2010based measures. Additionally, self\u2010reported mobility was measured on the Late Life Function and Disability Instrument (LLFDI). For neuromuscular attributes and LLFDI, scores in the lowest tertile indicated neuromuscular impairment or mobility limitations, respectively. For SPPB, a score &lt;7 (of 12) indicated severe mobility limitations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 430 participants (mean age\u2009=\u200977) most were female (68%), white (83%), and had either multisite (50%) or widespread (14%) pain. After adjusting for baseline characteristics, widespread pain (compared to none) was associated with slow leg speed (adjusted odds ratio, 95% confidence interval: aOR\u2009=\u20092.33, 1.03\u20105.27), limited ankle range of motion (aOR\u2009=\u20092.15, 1.03\u20104.47) and mobility limitations on LLFDI (aOR\u2009=\u20093.85, 1.81\u20108.19). Being in the highest pain intensity tertile, versus lowest tertile, was associated with poor trunk extensor muscle endurance (aOR\u2009=\u20092.49, 1.41\u20104.39), limited ankle range of motion (aOR\u2009=\u20092.15, 1.25\u20103.71), and mobility limitations on SPPB (aOR\u2009=\u20092.56, 1.45\u20104.52), and LLFDI (aOR\u2009=\u20094.70, 2.63\u20108.40).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among ambulatory, older primary care patients, more severe pain phenotypes are associated with neuromuscular impairments identified on physical testing and mobility limitations on validated measures.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pmrj.12336","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T12:16:07Z","timestamp":1580300167000},"page":"743-753","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Association of Pain Phenotype with Neuromuscular 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Harvard Medical School  Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie J.","family":"Keysor","sequence":"additional","affiliation":[{"name":"PhD Program in Rehabilitation Sciences MGH Institute of Health Professions  Boston MA"},{"name":"Department of Physical Therapy MGH Institute of Health Professions  Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven J.","family":"Atlas","sequence":"additional","affiliation":[{"name":"Department of Medicine, Harvard Medical School  Boston MA"},{"name":"Division of General Internal Medicine Massachusetts General Hospital  Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne G.","family":"Leveille","sequence":"additional","affiliation":[{"name":"College of Nursing and Health Sciences University of Massachusetts Boston  Boston MA"},{"name":"Department of Medicine Beth Israel Deaconess Medical Center  Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan F.","family":"Bean","sequence":"additional","affiliation":[{"name":"New England Geriatric Research Education and Clinical Center Boston Veterans Affairs Healthcare System  Boston MA"},{"name":"Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital  Cambridge MA"},{"name":"Department of Physical Medicine and Rehabilitation Harvard Medical School  Boston 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