{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:56:39Z","timestamp":1790420199738,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T00:00:00Z","timestamp":1603065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PM&amp;R"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Medial meniscal extrusion (MME) has been correlated with medial meniscal injury and progression of medial knee osteoarthritis (OA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the difference in MME between non\u2010weight\u2010bearing (supine) and weight\u2010bearing (standing) positions in patients with and without medial knee OA. Determine the correlation between body mass index (BMI), Kellgren\u2010Lawrence (KL) grade, Knee Osteoarthritis Outcome Score (KOOS), and MME.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary institution PM&amp;R Department.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Forty five participants (29 female, 16 male), 24 with healthy knees and 21 with OA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods or Interventions<\/jats:title><jats:p>A single physician sonographer measured supine and standing MME with ultrasound (US) on each participant. The physician was blinded to all measurements. BMI was recorded on all participants. KL grades and KOOS questionnaires were obtained for the OA group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>MME in supine and standing positions, change in MME from supine to standing, BMI, KL grade, and KOOS subscale scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MME increased .52\u2009mm from supine to standing (<jats:italic>P<\/jats:italic> &lt;\u2009.001). MME was greater in the OA group in both the supine (<jats:italic>P<\/jats:italic> =\u2009.002) and standing (<jats:italic>P<\/jats:italic> &lt;\u2009.001) positions. Increasing BMI was moderately correlated with increasing MME (supine <jats:italic>P<\/jats:italic> =\u2009.001, standing &lt;.001). Increasing age was correlated with increasing MME (supine <jats:italic>P<\/jats:italic> =\u2009.012, standing <jats:italic>P<\/jats:italic> =\u2009.002). Increasing KL grade (from 1 to 4) was correlated with increasing MME (supine <jats:italic>P<\/jats:italic> =\u2009.015, standing\u2009=\u2009.006). There was a small\u2010to\u2010moderate correlation between KOOS activities of daily living (ADL) subscale score and change in MME from supine to standing (<jats:italic>P<\/jats:italic> =\u2009.035). The change in MME from supine to standing positions had a small\u2010to\u2010moderate correlation (<jats:italic>P<\/jats:italic> =\u2009.035) with KOOS ADL subscale score alone but did not correlate with any of the other KOOS subscale scores or KOOS total scores. Receiver operating characteristic curve analysis suggested a standing MME value of 4.2\u2009mm provides a positive likelihood ratio of 6.02 for knee OA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MME is greater in those with OA and with weight\u2010bearing. MME correlates with BMI, age, KL grade, and the KOOS ADL subscale score. Finally, standing MME of 4.2\u2009mm yielded a higher positive likelihood ratio to differentiate between healthy knees and those with medial compartment OA than the previously reported value of 3.0\u2009mm.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pmrj.12450","type":"journal-article","created":{"date-parts":[[2020,7,11]],"date-time":"2020-07-11T21:33:25Z","timestamp":1594503205000},"page":"470-478","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The Difference in Medial Meniscal Extrusion between <scp>Non\u2010Weight\u2010Bearing<\/scp> and <scp>Weight\u2010Bearing<\/scp> Positions in People with and without Medial Compartment Knee Osteoarthritis"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9355-9388","authenticated-orcid":false,"given":"Jacob H.","family":"Reisner","sequence":"first","affiliation":[{"name":"Fellow, Primary Care Sports Medicine, Department of Physical Medicine and Rehabilitation Mayo Clinic College of Medicine and Science  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Franco","sequence":"additional","affiliation":[{"name":"Physician, Department of Physical Medicine and Rehabilitation Avera Medical Group  Sioux Falls SD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Hollman","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Mayo Clinic College of Medicine and Science  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam C.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic College of Medicine and Science  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob L.","family":"Sellon","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Mayo Clinic College of Medicine and Science  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3635-3919","authenticated-orcid":false,"given":"Jonathan T.","family":"Finnoff","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Mayo Clinic College of Medicine and Science  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24021"},{"issue":"9","key":"e_1_2_6_3_1","first-page":"1241","article-title":"The prevalence of chondrocalcinosis in the elderly and its association with knee osteoarthritis: the Framingham study","volume":"16","author":"Felson DT","year":"1989","journal-title":"J Rheumatol"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2010.03.001"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12110986"},{"issue":"12","key":"e_1_2_6_6_1","first-page":"1602","article-title":"Magnetic resonance imaging evidence of meniscal extrusion in medial meniscus posterior root tear","volume":"26","author":"Choi CJ","year":"2010","journal-title":"Art Ther"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2018.03.007"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket110"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.33319"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00776-014-0628-x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34353"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-018-4885-7"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.14.12522"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/2325967119S00233"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1941738111429419"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.1998.28.2.88"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.11088"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmrj.12183"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-014-0507-z"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-011-2234-z"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.183.1.1830017"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1875"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21460"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21724"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-11-201112060-00004"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.150052"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0800777"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.16.4.494"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-016-4732-4"}],"container-title":["PM&amp;R"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpmrj.12450","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pmrj.12450","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pmrj.12450","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pmrj.12450","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T07:55:51Z","timestamp":1693554951000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pmrj.12450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,19]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1002\/pmrj.12450"],"URL":"https:\/\/doi.org\/10.1002\/pmrj.12450","archive":["Portico"],"relation":{},"ISSN":["1934-1482","1934-1563"],"issn-type":[{"value":"1934-1482","type":"print"},{"value":"1934-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,19]]},"assertion":[{"value":"2020-01-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}