{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T23:00:38Z","timestamp":1774306838029,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T00:00:00Z","timestamp":1599782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PM&amp;R"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Botulinum toxin (BoNT) injections were shown to improve muscle tone of limbs in patients with spasticity. However, limited data are available regarding the effects of repeated BoNT injections on walking ability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess changes in walking velocity (WV), step length, and cadence under different test conditions after repeated treatment with abobotulinumtoxinA (aboBoNT\u2010A; Dysport) in spastic lower limb muscles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Secondary analysis of an open\u2010label, multiple\u2010cycle extension (National Clinical Trials number NCT01251367) to a phase III, double\u2010blind, randomized, placebo\u2010controlled, single\u2010treatment cycle study, in adults with chronic hemiparesis (NCT01249404).<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Fifty\u2010two centers across Australia, Belgium, the Czech Republic, France, Hungary, Italy, Poland, Portugal, Russia, Slovakia, and the United States.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>352 Ambulatory adults (18\u201080\u2009years) with spastic hemiparesis and gait dysfunction caused by stroke or traumatic brain injury, with a comfortable barefoot WV of 0.1 to 0.8\u00a0m\/s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>Up to four aboBoNT\u2010A treatment cycles, administered to spastic lower limb muscles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measurements<\/jats:title><jats:p>Changes from baseline in comfortable and maximal barefoot and with shoes WV (m\/s), step length (m\/step), and cadence (steps\/minutes).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At Week 12 after four injections, WV improved by 0.08 to 0.10\u00a0m\/s, step length by 0.03 to 0.04\u2009m\/step, and cadence by 3.9 to 6.2 steps\/minutes depending on test condition (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u2009.0001 to .0003 vs baseline). More patients (7% to 17%) became unlimited community ambulators (WV \u22650.8\u00a0m\/s) across test conditions compared with baseline, with 39% of 151 patients classified as unlimited community ambulators in at least one test condition and 17% in all four test conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Clinically meaningful and statistically significant improvements in WV, step length, and cadence under all four test conditions were observed in patients with spastic hemiparesis after each aboBoNT\u2010A treatment cycle.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pmrj.12459","type":"journal-article","created":{"date-parts":[[2020,8,2]],"date-time":"2020-08-02T08:48:05Z","timestamp":1596358085000},"page":"488-495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Effect of Repeated <scp>abobotulinumtoxinA<\/scp> (Dysport\u00ae) Injections on Walking Velocity in Persons 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