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Candidate psychosocial variables included self\u2010efficacy, social support, and motivation, measured using the Self\u2010Efficacy of Managing Chronic Disease questionnaire (SEMCD), Multidimensional Scale of Perceived Social Support questionnaire (MSPSS), and modified contemplation ladder (mCL), respectively. The hypothesis was that greater self\u2010efficacy, social support, and motivation would be associated with lower disability when controlling for covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The covariate model, including etiology, age, sex, U.S. military veteran status, LLA characteristics, time since LLA, medical complexity, and perceived functional capacity, explained 66.1% of disability variability (WHODAS 2.0). Backward elimination of candidate psychosocial variables stopped after removal of motivation (<jats:italic>P<\/jats:italic>\u2009=\u2009.10), with self\u2010efficacy (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) and social support (<jats:italic>P<\/jats:italic>\u2009=\u2009.002) variables remaining in the final model. The final model fit was statistically improved (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) and explained an additional 6.1% of disability variability when compared to the covariate model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Greater self\u2010efficacy and social support are related to lower disability after LLA. Findings suggest there may be a role for interventions targeting increased physical function, self\u2010efficacy, and social support for ambulatory prosthesis users after LLA in middle age or later, especially when complicated by multiple chronic conditions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pmrj.12464","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T09:07:43Z","timestamp":1597050463000},"page":"453-460","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Self\u2010Efficacy and Social Support are Associated with Disability for Ambulatory Prosthesis Users After Lower\u2010Limb Amputation"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1301-7149","authenticated-orcid":false,"given":"Matthew J.","family":"Miller","sequence":"first","affiliation":[{"name":"Department of Physical Therapy and Rehabilitation Science University of California, 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