{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T10:35:59Z","timestamp":1776508559891,"version":"3.51.2"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PM&amp;R"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Breast cancer survivors may have side effects from treatment, such as impaired upper limb function after surgery, which may be affected by a range of factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze the association between upper limb function and strength, fear avoidance, and central sensitization symptoms among breast cancer survivors, and to explore how these variables are associated with upper limb function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Validation cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Institutional practice at a public hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>One hundred seventy\u2010four breast cancer survivors who had been undergone surgery for a primary tumor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>Not applicable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measure<\/jats:title><jats:p>Upper limb function was measured by the Upper Limb Functional Index (ULFI\u2010Sp). Independent outcomes were: handgrip strength, which was measured using a Jamar dynamometer on the dominant side; fear avoidance, measured using the Fear\u2010Avoidance Components Scale (FACS\u2010Sp); and central sensitization symptoms, which were measured using the Central Sensitisation Inventory (CSI\u2010Sp). A linear regression model explaining the ULFI\u2010Sp results was constructed with the variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The regression model was significant (F\u00a0=\u00a046.826; <jats:italic>p<\/jats:italic>\u00a0&lt; .0001), and explained 45% of the variance of the ULFI values. All variables showed strong associations with upper limb function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Greater upper limb function is associated with higher grip strength, lower fear\u2010avoidance behavior and fewer central sensitization symptoms among breast cancer survivors. These variables explained 45% of the upper limb function in the regression model, and concur with earlier research showing that factors such as central sensitization symptoms and kinesiophobia negatively affect upper limb function in such patients. Clinicians should therefore take into account strength, fear avoidance, and central sensitization symptoms when considering interventions aimed at improving upper limb function among breast cancer survivors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pmrj.12731","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T06:47:00Z","timestamp":1635490020000},"page":"151-156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Factors associated with upper limb function in breast cancer survivors"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7355-9740","authenticated-orcid":false,"given":"Cristina","family":"Rold\u00e1n\u2010Jim\u00e9nez","sequence":"first","affiliation":[{"name":"Departamento de Fisioterapia, Facultad de Ciencias de la Salud Universidad de M\u00e1laga, Andaluc\u00eda Tech.  M\u00e1laga Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA), Grupo de Clinimetr\u00eda (F\u201014)  M\u00e1laga Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6143-6703","authenticated-orcid":false,"given":"Jaime","family":"Mart\u00edn\u2010Mart\u00edn","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA), Grupo de Clinimetr\u00eda (F\u201014)  M\u00e1laga Spain"},{"name":"Department of Human Anatomy, Legal Medicine and History of Science; Area of Legal Medicine University of M\u00e1laga, Faculty of Medicine  M\u00e1laga Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bella","family":"Pajares","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA)  M\u00e1laga Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuria","family":"Ribelles","sequence":"additional","affiliation":[{"name":"Hospital Universitario Virgen de la Victoria  M\u00e1laga Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Alba","sequence":"additional","affiliation":[{"name":"Hospital Universitario Virgen de la Victoria  M\u00e1laga Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8880-4315","authenticated-orcid":false,"given":"Antonio I.","family":"Cuesta\u2010Vargas","sequence":"additional","affiliation":[{"name":"Departamento de Fisioterapia, Facultad de Ciencias de la Salud Universidad de M\u00e1laga, Andaluc\u00eda Tech.  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