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Following the randomized protocol, a subset of participants also completed an open\u2010label, above\u2010threshold stimulation (AT\u2010SRS) condition. Children carried out the same uni\u2010manual and bimanual tasks during the randomized and open\u2010label protocols; all data were collected in a single session.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measure(s)<\/jats:title><jats:p>Box and Blocks (B&amp;B) test, a uni\u2010manual function test, and the Shriners Hospital Upper Extremity Evaluation (SHUEE). The SHUEE was video recorded and scored by two raters who were blinded to the experimental condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen children completed the B&amp;B task and 14 children completed the SHUEE. Children in the SBT\u2010SRS condition relative to sham condition moved an average of 1.8 more blocks in 1 minute (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.08); scored an average of 3 points higher on SHUEE spontaneous functional analysis (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.002); and scored an average of 2.7 points higher on SHUEE dynamic positional analysis (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.20). In the open\u2010label protocol, children in the AT\u2010SRS condition relative to sham moved 3.9 more blocks than in the sham condition (<jats:italic>n<\/jats:italic>\u00a0=\u00a08, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001); scored an average of 4.5 points higher on SHUEE spontaneous functional analysis (<jats:italic>n<\/jats:italic>\u00a0=\u00a06, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.08); and scored an average of 10.5 points higher on SHUEE dynamic positional analysis (<jats:italic>n<\/jats:italic>\u00a0=\u00a06, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion(s)<\/jats:title><jats:p>In this pilot study, we found preliminary evidence that children with hemiplegic cerebral palsy demonstrated improved uni\u2010manual abilities and increased function of the impaired hand on bimanual tasks when receiving a single session of SBT\u2010SRS. Preliminary evidence also suggests that some children with hemiplegic cerebral palsy may improve more when receiving a single session of AT\u2010SRS. Future research using larger, controlled studies should evaluate the optimal intensity, duration, and long\u2010term effect of SRS for improving impaired manual abilities.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pmrj.12788","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T02:39:34Z","timestamp":1645411174000},"page":"302-313","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of stochastic resonance stimulation on manual function in children with hemiplegic cerebral palsy: A pilot clinical trial"],"prefix":"10.1002","volume":"15","author":[{"given":"Jessica","family":"Lynn","sequence":"first","affiliation":[{"name":"Occupational Therapist: Children's Hospital of Richmond at VCU  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Wolf","sequence":"additional","affiliation":[{"name":"Occupational Therapist: Children's Hospital of Richmond at VCU  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Travis","family":"Bridges","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Virginia Commonwealth University Health Systems  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary","family":"Pottanat","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Virginia Commonwealth University School of Medicine  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Spivey","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Virginia Commonwealth University Health Systems  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8207-8845","authenticated-orcid":false,"given":"Olivier","family":"Rolin","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Virginia Commonwealth University Health Systems, Children's Hospital of Richmond  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,8]]},"reference":[{"issue":"1","key":"e_1_2_7_2_1","first-page":"91","article-title":"Cerebral palsy: an overview","volume":"73","author":"Krigger KW","year":"2006","journal-title":"AFP"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307389501000412"},{"key":"#cr-split#-e_1_2_7_4_1.1","unstructured":"HoneycuttA DunlapL ChenH HomsiG Grosse S. 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