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However, it is unknown how muscle oxygenation, the balance between delivery and utilization of oxygen at the muscle, is altered post\u2010stroke during aerobic exercise and how it relates to mobility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To monitor muscle oxygenation changes between the paretic and nonparetic legs of individuals after stroke during treadmill exercise and the 6\u2010minute walk test and analyze the association with mobility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Cardiac rehabilitation program.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Eleven male participants were enrolled in the study. Ten men (30.8\u2009\u00b1\u20094.1\u00a0months post\u2010stroke; age 63.9\u2009\u00b1\u200913.9\u2009years) with hemiparetic gait pattern finished the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods or interventions<\/jats:title><jats:p>Not applicable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Muscle oxygenation was measured with near\u2010infrared spectroscopy placed on the vastus lateralis of each leg during treadmill exercise at the first ventilatory threshold and during a 6\u2010minute walk test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The desaturation slope during treadmill exercise was significantly steeper (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.047) in the paretic (\u22120.7\u2009\u00b1\u20090.6%\/s) compared to the nonparetic leg (\u22120.3\u2009\u00b1\u20090.2%\/s). There was no other significant difference between legs. The 6\u2010minute walk test distance was not correlated with 6\u2010minute walk test muscle oxygenation in either leg (paretic: <jats:italic>r<\/jats:italic>\u00a0=\u00a00.20, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.590; nonparetic: <jats:italic>r<\/jats:italic>\u00a0=\u00a00.42, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.232).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>At the onset of treadmill exercise, the paretic leg was unable to effectively match the oxygen demand and extraction of the nonparetic leg, suggesting the need for an immediate cardiovascular warmup prior to initiating moderate intensity exercise in this population. Because the exercise desaturation rate is thought to indicate increased anaerobic metabolism and lactate production, efforts to delay rapid desaturation could improve the sustainability of activities of daily living and exercise.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pmrj.12927","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T19:04:32Z","timestamp":1670007872000},"page":"1239-1248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Muscle oxygenation of the paretic and nonparetic legs during and after exercise in chronic stroke: Implications for mobility"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8862-5926","authenticated-orcid":false,"given":"Elizabeth","family":"Whyte","sequence":"first","affiliation":[{"name":"Faculty of Kinesiology and Physical Education University of Toronto  Toronto Ontario Canada"},{"name":"KITE Research Institute Toronto Rehabilitation Institute \u2013 University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Thomas","sequence":"additional","affiliation":[{"name":"Faculty of Kinesiology and Physical Education University of Toronto  Toronto Ontario Canada"},{"name":"KITE Research Institute Toronto Rehabilitation Institute \u2013 University Health Network  Toronto Ontario Canada"},{"name":"Rehabilitation Sciences Institute University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3186-400X","authenticated-orcid":false,"given":"Susan","family":"Marzolini","sequence":"additional","affiliation":[{"name":"Faculty of Kinesiology and Physical Education University of Toronto  Toronto Ontario Canada"},{"name":"KITE Research Institute Toronto Rehabilitation Institute \u2013 University Health Network  Toronto Ontario Canada"},{"name":"Rehabilitation Sciences Institute University of Toronto  Toronto Ontario Canada"},{"name":"Canadian Partnership for Stroke Recovery  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,11]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Heart&Stroke.Different strokes: Recovery triumphs and challenges at any age. 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