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This scoping review aims to address the knowledge gap surrounding the characteristics of PCP following COVID\u201019, its causes, and potential treatments. This is a scoping review of 64 studies, including observational (prospective, retrospective, cross\u2010sectional, case series, and case\u2013control) and one quasi\u2010experimental study, from databases including Embase, PubMed\/MEDLINE, Cochrane CENTRAL, Google Scholar, Cochrane Database of Systematic Reviews, and Scopus. Studies on patients with PCP following mild, moderate, and severe COVID\u201019 infection were included. Studies with patients of any age, with chest pain that persisted following acute COVID\u201019 disease, irrespective of etiology or duration were included. A total of 35 studies reported PCP symptoms following COVID\u201019 (0.24%\u201376.6%) at an average follow\u2010up of 3\u2009months or longer, 12 studies at 1\u20133\u2009months and 17 studies at less than 1\u2010month follow\u2010up or not specified. PCP was common following mild\u2014severe COVID\u201019 infection, and etiology was mostly not reported. Fourteen studies proposed potential etiologies including endothelial dysfunction, cardiac ischemia, vasospasm, myocarditis, cardiac arrhythmia, pneumonia, pulmonary embolism, postural tachycardia syndrome, or noted cardiac MRI (cMRI) changes. Evaluation methods included common cardiopulmonary tests, as well as less common tests such as flow\u2010mediated dilatation, cMRI, single\u2010photon emission computed tomography myocardial perfusion imaging, and cardiopulmonary exercise testing. Only one study reported a specific treatment (sulodexide). PCP is a prevalent symptom following COVID\u201019 infection, with various proposed etiologies. Further research is needed to establish a better understanding of the causes and to develop targeted treatments for PCP following COVID\u201019.<\/jats:p>","DOI":"10.1002\/pmrj.13098","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T16:39:25Z","timestamp":1698770365000},"page":"605-625","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Persistent chest pain following <scp>COVID<\/scp>\u201019 infection \u2013 A scoping review"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8329-7705","authenticated-orcid":false,"given":"Eva","family":"Kubrova","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Mayo Clinic Rochester  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro J.","family":"Hallo\u2010Carrasco","sequence":"additional","affiliation":[{"name":"Department of Pain Medicine Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johana","family":"Klasova","sequence":"additional","affiliation":[{"name":"Department of Pain Medicine Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Pagan Rosado","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Mayo Clinic Rochester  Rochester Minnesota USA"},{"name":"Department of Pain Medicine Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian C.","family":"Prusinski","sequence":"additional","affiliation":[{"name":"Department of Pain Medicine Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleksandr","family":"Trofymenko","sequence":"additional","affiliation":[{"name":"Department of Pain Medicine Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin B.","family":"Schappell","sequence":"additional","affiliation":[{"name":"Department of Pain Medicine Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry J.","family":"Prokop","sequence":"additional","affiliation":[{"name":"Library and Public Services Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara I.","family":"Yuh","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahil","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pain Medicine Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0507-7889","authenticated-orcid":false,"given":"Christine L.","family":"Hunt","sequence":"additional","affiliation":[{"name":"Department of Pain Medicine Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2021.12.017"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh-2021-005427"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003773"},{"key":"e_1_2_7_5_1","unstructured":"WHO.Fact sheet: Post\u2010COVID\u201019 condition (Long COVID).https:\/\/www.who.int\/europe\/news-room\/fact-sheets\/item\/post-covid-19-conditionPublished 2022. 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