{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:06:06Z","timestamp":1792191966940,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100021528","name":"Advancing a Healthier Wisconsin Endowment","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100021528","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["2UL1TR001436"],"award-info":[{"award-number":["2UL1TR001436"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PM&amp;R"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The Buffalo Concussion Treadmill Test (BCTT) is used to establish exercise tolerance for rehabilitation and identify injury subtypes for youth athletes after mild traumatic brain injury (mTBI). Its utility in adult community members is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Primary: To describe how adults with and without mTBI tolerate the BCTT. Secondary: To explore relationships between baseline factors, mTBI\u2010related symptoms, and BCTT duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective, observational, longitudinal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Academic medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Thirty\u2010seven adults treated in a level 1 trauma center emergency department with mTBI; \u200924 uninjured controls (UC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>N\/A.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Measures<\/jats:title><jats:p>Participants completed two visits 3\u2009weeks apart (1\u2009week and 1\u2009month after mTBI) including a 15\u2010minute BCTT, the Rivermead Post Concussion Symptoms Questionnaire (RPQ), and preinjury International Physical Activity Questionnaire. Analyses characterized BCTT response and associations between baseline factors, RPQ scores, and BCTT duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Persons with mTBI discontinued earlier than UC at 1\u2010week postinjury using standard discontinuation criteria for exercise intolerance. The percentage of mTBI participants with signs of possible mTBI\u2010related intolerance was 55.6% at 1\u2009week (36.1% for mTBI\u2010related symptom exacerbation, 19.4% for exertion\/fatigue before reaching 85% of one's age\u2010predicted maximum heart rate [HR]) and 48.0% at 1\u2009month (40.0% mTBI\u2010related symptom exacerbation, 8.0% exertion without reaching the target HR). Thirty percent of UCs completed the BCTT at both assessments. UCs met discontinuation criteria for increased nonspecific symptoms (eg, pain\/general discomfort and increased Visual Analog Scale ratings; 39\u201361%) and physical exertion (9\u201326%). Shorter duration was associated with higher body mass index (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.42 \u2013 \u22120.45), shorter height (<jats:italic>r<\/jats:italic>\u2009=\u20090.22\u20130.29), female gender (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.26 \u2013 \u22120.27), and greater RPQ symptoms (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.28 \u2013 \u20100.47).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The BCTT exacerbates mTBI\u2010related symptoms in adult community members. Participant characteristics and noninjury factors influence performance. The findings imply the BCTT could be useful in clinical assessments of adults with mTBI. Interpretation should account for the unique characteristics of nonathletes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pmrj.13132","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T13:19:25Z","timestamp":1709039965000},"page":"826-835","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Use of the Buffalo Concussion Treadmill Test in community adult patients with mild traumatic brain injury"],"prefix":"10.1002","volume":"16","author":[{"given":"Andrew","family":"DeGroot","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L.","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Leddy","sequence":"additional","affiliation":[{"name":"UBMD Orthopaedics and Sports Medicine; SUNY Buffalo Jacobs School of Medicine and Biomedical Sciences  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hershel","family":"Raff","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery, and Physiology Medical College of Wisconsin, Milwaukee WI and the Endocrine Research Laboratory, Aurora St. Luke's Medical Center, Advocate Aurora Research Institute  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"McCrea","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blair D.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Kinesiology Indiana University  Bloomington Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5258-953X","authenticated-orcid":false,"given":"Lindsay D.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss6609a1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/HTR.0000000000000187"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2018.4288"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2013.11.004"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2018.6172"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2016.4618"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.1313"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.19.2549"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3233\/NRE-2007-22306"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1997.86.3.0425"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3233\/NRE\u2010172298"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2016.00013"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1998.275.4.R1287"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014\u20100966"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports\u20102017\u2010097878"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1249\/JSR.0000000000000505"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20104642(21)00267\u20104"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/JSM.0000000000000431"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2018.4397"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000611"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/16501960410023859"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.19771"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001199-199309000-00009"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1249\/JSR.0000000000000008"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00868811"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000078924.61453.FB"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479\u20105868\u20106\u201021"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3109\/02699052.2014.965207"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.4988"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwab169"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509332497"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsams.2021.04.005"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/1941738119870189"}],"container-title":["PM&amp;R"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pmrj.13132","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T11:06:29Z","timestamp":1723460789000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pmrj.13132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,27]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/pmrj.13132"],"URL":"https:\/\/doi.org\/10.1002\/pmrj.13132","archive":["Portico"],"relation":{},"ISSN":["1934-1482","1934-1563"],"issn-type":[{"value":"1934-1482","type":"print"},{"value":"1934-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,27]]},"assertion":[{"value":"2023-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}