{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:54:27Z","timestamp":1792050867273,"version":"4.4.0"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["1 I01 RX002919R\u201001"],"award-info":[{"award-number":["1 I01 RX002919R\u201001"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PM&amp;R"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the prevalence of peripheral neuropathy (PN) and its effect on mobility in patients who were prescribed a lower limb prosthesis (LLP) after an incident dysvascular transtibial (TT) or transfemoral (TF) lower extremity amputation (LEA). We also sought to determine if the effect of PN on mobility was modified by amputation level or depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Participants were identified retrospectively through the Veterans Affairs (VA) Corporate Data Warehouse (CDW) from March 1, 2018, to November 30, 2020, then were contacted prospectively to obtain their self\u2010reported mobility. Multiple logistic regression was used to control for potential confounders and identify potential effect modifiers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>The VA CDW, the National Prosthetics Patient Database, participant mailings and phone calls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Three hundred fifty\u2010seven individuals who underwent a TT or TF amputation due to diabetes and\/or peripheral arterial disease and were fitted with a qualifying LLP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>Not applicable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcomes Measures<\/jats:title><jats:p>The Locomotor Capabilities Index <jats:italic>basic<\/jats:italic> and <jats:italic>advanced mobility<\/jats:italic> subscale scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two\u2010hundred thirty seven participants (66%) had a diagnosis of PN prior to prosthesis prescription. The detrimental effect of PN on achieving <jats:italic>basic<\/jats:italic> and <jats:italic>advanced mobility<\/jats:italic> was significant after adjusting for potential confounding factors (adjusted odds ratio [aOR],\u20090.53; 95% confidence interval [CI], 0.30\u20130.94; <jats:italic>p<\/jats:italic>\u2009=\u2009.03 and aOR,\u20090.43; 95% CI, 0.24\u20130.77; <jats:italic>p<\/jats:italic>\u2009=\u2009.005, respectively). The detrimental effect of PN was more pronounced in patients with depression, especially for <jats:italic>advanced mobility<\/jats:italic> (aOR,\u20090.36; 95% CI, 0.14\u20130.95; <jats:italic>p<\/jats:italic>\u2009=\u2009.04) versus no depression (aOR,\u20090.53; 95% CI, 0.27\u20131.0; <jats:italic>p<\/jats:italic>\u2009=\u2009.07).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PN is common in patients who have undergone an LEA due to diabetes and\/or vascular disease and patients with this diagnosis should be carefully evaluated. Targeted rehabilitation programs to mitigate its potential detrimental effects on mobility are important and should specifically include mental health assessment and treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pmrj.13253","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T09:54:36Z","timestamp":1724925276000},"page":"159-169","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Peripheral neuropathy prevalence and effect on mobility 12\u2009months after prosthesis prescription among individuals with dysvascular lower extremity amputation"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4386-2677","authenticated-orcid":false,"given":"Daniel C.","family":"Norvell","sequence":"first","affiliation":[{"name":"VA Puget Sound Health Care System  Seattle Washington USA"},{"name":"Department of Rehabilitation Medicine University of Washington  Seattle 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