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Considering the impact of muscle strength on walking ability, resistance training may have the potential to improve walking speed in MS. Therefore, this systematic review and meta\u2010analysis aims to evaluate the effect of lower limb resistance training on walking speed in people with MS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seven databases (CINAHL, MEDLINE, The Allied and Complimentary Medicine Database, Web of Science, Physiotherapy Evidence Database [PEDro], PsycINFO, and Sports Medicine and Education Index) were searched in March 2024 for studies that met the following eligibility criteria: randomized controlled trials investigating the effects of resistance training interventions on objective measures of walking speed in people with MS. Risk of bias was assessed using the PEDro scale. Meta\u2010analysis was performed to quantify intervention effect using a random effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve randomized controlled trials were included, reporting data on 425 individuals with MS. Participants had mostly relapsing\u2013remitting MS (85%) and a mild\u2013moderate level of disability (Expanded Disability Status Score 1.0\u20136.0). Results of the meta\u2010analysis (based on 7 of the included studies) indicated a significant yet variable improvement in walking speed in favor of the intervention (0.10\u2009m\/s, 95% confidence interval 0.01\u20130.19, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Sensitivity analysis indicates that larger improvements in walking speed were found over tests covering shorter distances.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Resistance training was found to significantly improve walking speed in people with MS. However, variability in results were noted across studies; accordingly, future research should determine how variables\u2014particularly related to resistance training prescription\u2014influence the intervention effect.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pmrj.13255","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T11:40:10Z","timestamp":1727091610000},"page":"222-237","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Changes in walking speed following resistance training in people with multiple sclerosis: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"17","author":[{"given":"Connor","family":"McManaman","sequence":"first","affiliation":[{"name":"School of Health and Life Sciences Glasgow Caledonian University  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brianna","family":"Novak","sequence":"additional","affiliation":[{"name":"School of Health and Life Sciences Glasgow Caledonian University  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorna","family":"Paul","sequence":"additional","affiliation":[{"name":"School of Health and Life Sciences Glasgow Caledonian University  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4309-2382","authenticated-orcid":false,"given":"Scott","family":"Rooney","sequence":"additional","affiliation":[{"name":"School of Health and Life Sciences Glasgow Caledonian University  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)30481\u20101"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010011\u20105963\u20107"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638280902751931"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2165\/11591150\u2010000000000\u201000000"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/2055217317728301"},{"issue":"3","key":"e_1_2_8_7_1","first-page":"127","article-title":"A survey of multiple sclerosis: II. 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