{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T11:09:39Z","timestamp":1778324979929,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016156","name":"U.S. Army Medical Research and Development Command","doi-asserted-by":"publisher","award":["W81XWH1810760"],"award-info":[{"award-number":["W81XWH1810760"]}],"id":[{"id":"10.13039\/100016156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PM&amp;R"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Persistent postural\u2010perceptual dizziness (PPPD) is a chronic functional vestibular disorder that is a potential sequela of traumatic brain injury (TBI). Currently, little is known about how patients with TBI associated PPPD respond to typical PPPD treatment modalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To\u00a0investigate the prevalence of TBI as a precipitant for PPPD and assess outcomes of usual treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Electronic medical records from a tertiary care center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Patients \u226518\u2009years of age diagnosed with PPPD secondary to TBI between January 2015 and December 2022 who underwent 6\u2009months of treatment with at least one return clinic visit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>Not applicable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measure(s)<\/jats:title>\n                    <jats:p>Patients' best clinical global impression\u2010improvement scale (CGI\u2010I) score following 6\u2009months of treatment were collected and then compared with previously published literature, with CGI\u2010I scores of 1 or 2 (indicating the patient was \u201cvery much\u201d or \u201cmuch\u201d improved, respectively) considered treatment responders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 134 (8.9%) of 1503 patients had a TBI as the triggering event for PPPD. The mean age of this cohort was 47.6\u2009years with most of these cases occurring after a mild TBI (85.8%). The proportion of females with post\u2010TBI PPPD (58.2%) was significantly lower than the proportion with PPPD due to all causes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.037). The most common treatment prescribed was vestibular therapy (82.2%), and 53.3% of patients were considered treatment responders after 6\u2009months. Patients with TBI\u2010induced PPPD had a significantly worse mean CGI\u2010I score (2.49\u2009\u00b1\u20091.1) when compared to prior literature (1.71\u2009\u00b1\u20090.83) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study found\u00a0a 9% prevalence of PPPD following TBI in the largest cohort studied to date. Patients who developed PPPD following TBI did not respond as well to standard treatments as patients with other causes of the disorder, and thus may require closer clinical follow\u2010up to assess treatment efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pmrj.13339","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T06:24:21Z","timestamp":1739514261000},"page":"621-627","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prevalence and treatment outcomes of persistent postural\u2010perceptual dizziness after traumatic brain injury"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3193-4680","authenticated-orcid":false,"given":"Brandon","family":"Johnson","sequence":"first","affiliation":[{"name":"Mayo Clinic Department of Physical Medicine and Rehabilitation  Rochester Minnesota 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