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However, allo\u2010HSCT can lead to adverse effects, such as reduced physical function. Exercise has demonstrated benefits in post\u2010allo\u2010HSCT recovery, but feasibility issues persist in tailored prehabilitation interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To present a multiphasic exercise prehabilitation protocol.The study aims to assess feasibility, safety, and impact while establishing screening and referral pathways to community\u2010based exercise oncology resources.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Single arm feasibility study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Individuals diagnosed with acute leukemia and eligible for allo\u2010HSCT will be recruited for the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Intervention<\/jats:title><jats:p>Multimodal exercise and health behavior change support that will span across the allo\u2010HSCT timeline (ie, pre\u2010, during, and post\u2010transplant phases). Clinical exercise physiologists trained in exercise oncology and health behavior change will deliver the intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Assessment of physical function, self\u2010reported and objective physical activity, quality of life, fatigue, anxiety, depression, and symptom burden across four timepoints (baseline, pre\u2010transplant, post\u2010transplant inpatient recovery, and post\u2010transplant outpatient recovery).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study is designed to address current limitations in prehabilitation literature specific to individuals with acute leukemia receiving allo\u2010HSCT. In turn, this study may offer an approach to maintain or improve physical function and quality of life throughout the transplant continuum.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pmrj.13351","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T05:11:48Z","timestamp":1743052308000},"page":"917-926","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A single\u2010arm feasibility study protocol for a multiphasic multimodal exercise prehabilitation intervention in individuals receiving allogeneic stem cell transplant"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4930-4238","authenticated-orcid":false,"given":"Chad W.","family":"Wagoner","sequence":"first","affiliation":[{"name":"Faculty of Kinesiology University of Calgary  Calgary Alberta Canada"},{"name":"Department of Community Health Sciences, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Ohlson Research Initiative, Arnie Charbonneau Research Institute, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Department of Kinesiology, Recreation, and Sport Studies University of Tennessee  Knoxville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia T.","family":"Daun","sequence":"additional","affiliation":[{"name":"Faculty of Kinesiology University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jocelyn","family":"Cannon","sequence":"additional","affiliation":[{"name":"Faculty of Kinesiology University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Danyluk","sequence":"additional","affiliation":[{"name":"Faculty of Kinesiology University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Langelier","sequence":"additional","affiliation":[{"name":"Department of Oncology, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Department of Psychosocial Resources, Tom Baker Cancer Centre, Alberta Health Services  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George J.","family":"Francis","sequence":"additional","affiliation":[{"name":"Department of Psychosocial Resources, Tom Baker Cancer Centre, Alberta Health Services  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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