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This interplay involves complex mechanisms, including proinflammatory mediators in nociceptive modulation and pain\u2010induced lifestyle changes affecting metabolic function. This scoping review examines the association between MetS and chronic pain. We conducted a scoping review, including 28 studies. This review followed the Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses Extension for Scoping Reviews guidelines. We included observational studies (cross\u2010sectional, case\u2013control, and cohort studies) from the following databases: Ovid MEDLINE, EMBASE, Cochrane Central, Cochrane Database of Systematic Reviews, and Scopus. We identified studies on migraine (<jats:italic>n<\/jats:italic>\u2009=\u20099), spinal pain (<jats:italic>n<\/jats:italic>\u2009=\u20098), general chronic pain (<jats:italic>n<\/jats:italic>\u2009=\u20094), fibromyalgia syndrome (<jats:italic>n<\/jats:italic>\u2009=\u20093), carpal tunnel syndrome (<jats:italic>n<\/jats:italic>\u2009=\u20091), osteoarthritis (<jats:italic>n<\/jats:italic>\u2009=\u20091), shoulder pain (<jats:italic>n<\/jats:italic>\u2009=\u20091), and neuropathic pain (<jats:italic>n<\/jats:italic>\u2009=\u20091). Most studies used a cross\u2010sectional design and standard criteria to define MetS, with some exceptions. Individuals with MetS and spinal pain, fibromyalgia, or general chronic pain showed higher pain scores and increased functional limitations. MetS was common in patients with migraine, but its effect on pain severity was inconclusive. The relationship between MetS and other pain conditions requires further investigation to clarify the association and potential mechanisms. MetS is prevalent in patients with chronic pain and is associated with worse pain and functional outcomes. Health care providers should acknowledge the wide spectrum of MetS beyond obesity. This understanding may help identify those at risk for more severe chronic pain.<\/jats:p>","DOI":"10.1002\/pmrj.13361","type":"journal-article","created":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T08:57:21Z","timestamp":1742029041000},"page":"1107-1119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The association between chronic pain and metabolic syndrome: A scoping review"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0657-6089","authenticated-orcid":false,"given":"Sebastian","family":"Encalada","sequence":"first","affiliation":[{"name":"Department of Pain Medicine Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"Atchison","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Mayo Clinic  Jacksonville Florida 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