{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:25:36Z","timestamp":1792113936353,"version":"4.4.0"},"reference-count":103,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PM&amp;R"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the effects of exercise programs on exercise\u2010induced hypoalgesia in people with chronic musculoskeletal pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Literature Survey<\/jats:title>\n                    <jats:p>This systematic review and meta\u2010analysis included a search of MEDLINE, Web of Science, CINAHL, SCOPUS, and EMBASE databases from inception until May 18, 2025. Randomized controlled trials that examined aerobic or anaerobic exercise interventions in patients with chronic musculoskeletal pain and that assessed pressure pain thresholds were considered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>The Hartung\u2010Knapp\u2010Sidik\u2010Jonkman random\u2010effects method or Mantel\u2013Haenszel fixed\u2010effects method, depending on the heterogeneity, was applied to estimate the effects of exercise\u2010induced hypoalgesia. The risk of bias was assessed with the risk of bias 2 tool and the certainty of the evidence was evaluated with Grading of Recommendations Assessment, Development, and Evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Synthesis<\/jats:title>\n                    <jats:p>Nineteen articles were included. The meta\u2010analysis found a small statistically significant difference in favor of other physical therapy treatments compared with isolated exercise for pressure pain thresholds in both individuals with chronic neck\u2010shoulder pain and those with chronic low back pain pain, with low and very low certainty of the evidence, respectively. For the overall risk of bias, 2 studies had a low risk, 6 had some concerns, and 11 had a high risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Isolated exercise in people with chronic neck and shoulder pain and those with chronic low back pain is not superior to other therapeutic modalities for improving pressure pain thresholds. Other physical therapy modalities generate higher pressure pain thresholds than isolated exercise with small effect size. These findings should be interpreted with caution due to the limited certainty of the evidence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pmrj.70120","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T11:16:59Z","timestamp":1775128619000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of exercise\u2010induced hypoalgesia on pressure pain threshold in patients with chronic musculoskeletal pain: A systematic review and meta\u2010analysis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7827-7120","authenticated-orcid":false,"given":"Joaqu\u00edn","family":"Salazar\u2010M\u00e9ndez","sequence":"first","affiliation":[{"name":"Escuela de Ciencias del Deporte y Actividad F\u00edsica, Facultad de Salud Universidad Santo Tom\u00e1s  Talca 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