{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:07:57Z","timestamp":1789456077605,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PM&amp;R"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate adverse events (AEs) associated with intra\u2010articular platelet\u2010rich plasma (IA\u2010PRP) injections for knee osteoarthritis (KOA) and compare their rates with those of intra\u2010articular corticosteroids (IA\u2010CS), hyaluronic acid (IA\u2010HA), and normal saline (IA\u2010NS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Literature Survey<\/jats:title>\n                    <jats:p>A systematic search of PubMed, Embase, and Cochrane Library databases identified randomized controlled trials (RCTs) published after 2015. Studies were included if they reported AEs related to IA\u2010PRP injections for KOA and provided comparator data for IA\u2010CS, IA\u2010HA, or IA\u2010NS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>Data on AEs were extracted and categorized into mild knee pain and swelling, severe knee pain requiring withdrawal, knee stiffness, other musculoskeletal (MSK) events, non\u2010MSK events, and severe AEs. A random\u2010effects meta\u2010analysis was performed to calculate odds ratios (OR) with 95% confidence intervals (CI) for AE rates in IA\u2010PRP versus comparator groups. Subgroup analysis was conducted to evaluate the effects of leukocyte concentration on AE rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Synthesis<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010two RCTs published articles, involving 1268 IA\u2010PRP\u2010treated knees, met inclusion criteria. AEs were reported in 18.7% of IA\u2010PRP cases, with mild knee pain and swelling being the most common (10.6%). Compared to IA\u2010HA, IA\u2010PRP had significantly higher rates of mild knee pain and swelling (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). Subgroup analysis revealed that this difference was significant only for leukocyte\u2010rich IA\u2010PRP (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05), whereas leukocyte\u2010poor IA\u2010PRP showed no significant difference compared to IA\u2010HA (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.51). Knee stiffness was more frequent in IA\u2010PRP versus IA\u2010NS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.031). There were no significant differences in other AE categories, and no severe AEs were reported across any groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IA\u2010PRP injections are associated with mild, transient AEs such as knee pain and swelling, particularly with leukocyte\u2010rich PRP formulations. These symptoms typically resolve without intervention. Leukocyte\u2010poor IA\u2010PRP showed a similar safety profile to IA\u2010HA. No severe AEs were observed, supporting the overall safety of IA\u2010PRP for KOA. Clinicians should counsel patients on the likelihood of mild postprocedure symptoms, especially with high leukocyte formulations, while considering IA\u2010PRP as a treatment option.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pmrj.70141","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:04:16Z","timestamp":1778241856000},"page":"1072-1084","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of adverse events and safety associated with intra\u2010articular platelet\u2010rich plasma injections compared to other injectates for knee osteoarthritis: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7491-4986","authenticated-orcid":false,"given":"Hirotaka F.","family":"Nakagawa","sequence":"first","affiliation":[{"name":"UC Davis Medical Center  Sacramento California 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