{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T22:42:51Z","timestamp":1786747371618,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100023771","name":"Fabrikant Vilhelm Pedersen og Hustrus Legat","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023771","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005860","name":"Helsefonden","doi-asserted-by":"publisher","award":["19\u2010B\u20100087"],"award-info":[{"award-number":["19\u2010B\u20100087"]}],"id":[{"id":"10.13039\/501100005860","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007403","name":"Dagmar Marshalls Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007403","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008267","name":"Kong Christian den Tiendes Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008267","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010809","name":"Jascha Fonden","doi-asserted-by":"publisher","award":["2021\u20100002"],"award-info":[{"award-number":["2021\u20100002"]}],"id":[{"id":"10.13039\/100010809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008266","name":"K\u00f8bmand I Odense Johan og Hanne Weimann F\u00f8dt Seedorffs Legat","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010363","name":"Minister Erna Hamiltons Legat for Videnskab og Kunst","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PM&amp;R"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Aerobic exercise is beneficial in managing Parkinson disease (PD), yet its potential remains less clear in early stages. This study investigates the impact of long\u2010term aerobic exercise habits in individuals with early\u2010stage PD compared with healthy controls.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Cross\u2010sectional study.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To evaluate whether long\u2010term exposure to moderate\u2010 to high\u2010intensity exercise was associated with more favorable physical, cognitive, and patient\u2010reported outcomes in early PD, by comparing \u201chighly active\u201d individuals (self\u2010reported moderate\u2010 to high\u2010intensity aerobic exercise \u2265 twice weekly for >3 months) with \u201clow\u2010active\u201d individuals (self\u2010reported moderate\u2010 to high\u2010intensity aerobic exercise \u2264 twice weekly for >3 months) and healthy controls.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n University.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n Seventy\u00a0low\u2010active individuals with PD, 35 highly active individuals with PD, and 35 healthy controls were included.<\/jats:p>\n <\/jats:sec>\n \n Interventions<\/jats:title>\n Not applicable.<\/jats:p>\n <\/jats:sec>\n \n Main Outcome Measure(s)<\/jats:title>\n Assessments included Timed Up and Go Test, Six Spot Step Test, 6\u2010Minute Walk Test, Mini Balance Evaluation Systems Test, Lower Extremity Muscle Peak Power, Aerobic Capacity, Physical Activity, Montreal Cognitive Assessment, Symbol Digit Modalities Test, Parkinson's Disease Questionnaire, Non\u2010Motor Symptoms Questionnaire, Falls Efficacy Scale\u2010International, European Quality of Life Questionnaire, Beck Depression Inventory\u2010II, and Movement Disorders Society\u2010sponsored revision of the Unified Parkinson's Disease Rating Scale.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Highly active individuals with PD outperformed low\u2010active individuals with PD (\n p<\/jats:italic>\n \u2009<\u2009.05) in physical function outcomes, motor symptom severity, physical activity levels, and nonmotor symptoms, while showing comparable results to healthy controls across several tests covering physical and cognitive function and physical activity level. Low\u2010active participants showed impairments in several physical function and activity outcomes relative to healthy controls (\n p<\/jats:italic>\n \u2009<\u2009.05). Cognitive function outcomes were comparable across the PD groups, but healthy controls performed better in processing speed (\n p<\/jats:italic>\n \u2009<\u2009.05). No significant differences were found between participant groups in quality of life or depressive symptoms.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Regular engagement in moderate\u2010 to high\u2010intensity aerobic exercise in early PD may preserve physical function, suggesting a potential role in limiting disease\u2010related motor decline. These findings support the consideration of early, high\u2010intensity aerobic exercise interventions as part of a comprehensive management strategy for PD.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/pmrj.70145","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T03:46:35Z","timestamp":1782186395000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Physical activity and exercise participation\u2014Impact on motor and non\u2010motor outcomes in early\u2010stage\n Parkinson<\/scp>\n disease: A cross\u2010sectional study"],"prefix":"10.1002","author":[{"given":"Cecilie","family":"Thrue","sequence":"first","affiliation":[{"name":"Exercise Biology, Department of Public Health Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Bonde\u2010Jensen","sequence":"additional","affiliation":[{"name":"Exercise Biology, Department 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