{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:41:08Z","timestamp":1792172468626,"version":"4.4.0"},"reference-count":64,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["19\/690"],"award-info":[{"award-number":["19\/690"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021732","name":"Aotearoa Foundation","doi-asserted-by":"publisher","award":["9909494"],"award-info":[{"award-number":["9909494"]}],"id":[{"id":"10.13039\/501100021732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Paediatric and Neonatal Pain"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This overview of systematic reviews aimed to identify effective pain management strategies for neonatal blood sampling. Searches were conducted in four databases from 2014 to April 2026. Eligible studies were systematic reviews including randomized or quasi\u2010randomized controlled trials assessing pain management in neonates during blood sampling. Reviews were required to have searched at least two databases within the past 10\u2009years, reported their search strategy, and conducted a risk\u2010of\u2010bias assessment. The search identified 2463 records; 22 reviews (13 Cochrane and two non\u2010Cochrane pairwise reviews, and seven network meta\u2010analyses) met inclusion criteria. Interventions evaluated included opioids, paracetamol, topical anesthetics, breastfeeding or breastmilk, sucrose, music medicine, acupuncture, and other non\u2010pharmacological methods. Sucrose with or without non\u2010nutritive sucking was effective in reducing pain scores during heel pricks in preterm and term neonates (mean difference \u22121.74, 95% confidence interval [\u22122.11, \u22121.37], moderate\u2010certainty). Skin\u2010to\u2010skin contact also reduced pain scores compared with control (mean difference \u22123.47 [\u22125.55, \u22121.38], moderate\u2010certainty). Recent network meta\u2010analyses generally supported parent\u2010led interventions and oral sweet solutions as the most effective strategies. Breastfeeding, supplemental breastmilk, acupuncture, and light reduction were promising but require further evidence. For other interventions, evidence was insufficient to draw conclusions. Evidence from systematic reviews and network meta\u2010analyses indicates that sucrose and skin\u2010to\u2010skin contact effectively reduce procedural pain in neonates. Parent\u2010led and other non\u2010pharmacological interventions, including breastfeeding, also appear beneficial and should increasingly be considered part of family\u2010centred neonatal pain care where feasible.<\/jats:p>","DOI":"10.1002\/pne2.70044","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T08:50:33Z","timestamp":1788857433000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pain Management During Neonatal Blood Sampling: An Overview of Systematic Reviews"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2562-2905","authenticated-orcid":false,"given":"Libby G.","family":"Lord","sequence":"first","affiliation":[{"name":"Liggins Institute, University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2697-1422","authenticated-orcid":false,"given":"Jane E.","family":"Harding","sequence":"additional","affiliation":[{"name":"Liggins Institute, University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9079-4451","authenticated-orcid":false,"given":"Caroline A.","family":"Crowther","sequence":"additional","affiliation":[{"name":"Liggins Institute, University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8448-1504","authenticated-orcid":false,"given":"Luling","family":"Lin","sequence":"additional","affiliation":[{"name":"Liggins Institute, University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.06.044"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjmed-2023-000544"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000492859"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-3851"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-023-3032-9"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.72.1.F47"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.02.014"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.05.022"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003411"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1521"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000808"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884217504263267"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2014.01.005"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e3182906aed"},{"issue":"6","key":"e_1_2_10_16_1","first-page":"59","article-title":"The Development of a Tool to Assess Neonatal Pain","volume":"12","author":"Lawrence J.","year":"1993","journal-title":"Neonatal Network: NN"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-693X(97)83360-X"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(87)90073-X"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2009.185"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.infbeh.2017.09.002"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13839"},{"key":"e_1_2_10_22_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 65","author":"Pollock M.","year":"2024"},{"key":"e_1_2_10_23_1","volume-title":"Covidence Systematic Review Software","author":"Veritas Health Innovation","year":"2026"},{"key":"e_1_2_10_24_1","volume-title":"GRADE Handbook for Grading Quality of Evidence and Strength of Recommendations","author":"Sch\u00fcnemann H.","year":"2013"},{"key":"e_1_2_10_25_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions (Version 65)","author":"Sch\u00fcnemann H. 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