{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:25:21Z","timestamp":1791559521484,"version":"4.3.4"},"reference-count":67,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Portal Hypertension &amp;amp; Cirrhosis"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Metabolic dysfunction\u2010associated steatotic liver disease (MASLD) is a rapidly increasing chronic disease worldwide, particularly among patients with type 2 diabetes. Its severe form, metabolic dysfunction\u2010associated steatohepatitis (MASH), is also on the rise. The treatment of MASLD and MASH poses significant challenges. Thyroid hormones and their receptors thyroid hormone receptor (TR) agonists, especially resmetirom, have shown potential in improving metabolism and reducing liver inflammation. Thyroid hormones play a crucial role in regulating metabolism and maintaining physiological balance. However, in patients with MASLD, there is a reduced conversion of 3,3\u2032,5,5\u2032\u2010tetraiodo\u2010\n                    <jats:sc>l<\/jats:sc>\n                    \u2010thyronine (T\n                    <jats:sub>4<\/jats:sub>\n                    ) to biologically active 3,5,3\u2032\u2010triiodo\u2010\n                    <jats:sc>l<\/jats:sc>\n                    \u2010thyronine (T\n                    <jats:sub>3<\/jats:sub>\n                    ), resulting in decreased T\n                    <jats:sub>3<\/jats:sub>\n                    levels and impaired hepatic TR signaling. This hormonal imbalance is associated with disrupted hepatic lipid metabolism. Resmetirom, an oral selective TR agonist that specifically targets hepatocytes, was approved by the Food and Drug Administration (FDA) in March 2024 for the treatment of moderate to severe liver fibrosis in non\u2010cirrhotic adults with MASH. This approval was based on the results of the MAESTRO clinical program, which includes multiple\u2010stage research designs such as the MAESTRO\u2010NASH, MAESTRO\u2010NAFLD\u20101, MAESTRO\u2010NAFLD\u2010OLE, and MAESTRO\u2010NASH\u2010OUTCOMES, aims to evaluate the efficacy and safety of resmetirom in different populations of MASH patient. Although the approval of resmetirom represents a significant milestone in the treatment of MAFLD and MASH, many questions remain regarding its long\u2010term effectiveness and impact on clinical outcomes. Ongoing research, particularly through the MAESTRO program, holds promise for providing additional insights into the long\u2010term management of MASLD using resmetirom and other similar medications.\n                  <\/jats:p>","DOI":"10.1002\/poh2.100","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T06:56:47Z","timestamp":1737529007000},"page":"66-78","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Resmetirom and Thyroid Hormone Receptor\u2010Targeted Treatment for Metabolic Dysfunction\u2010Associated Steatotic Liver Disease (MASLD)"],"prefix":"10.1002","volume":"4","author":[{"given":"Chang\u2010Hai","family":"Liu","sequence":"first","affiliation":[{"name":"Center of Infectious Diseases, West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"Laboratory of Infectious and Liver Diseases, Institute of Infectious Diseases, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing\u2010Min","family":"Zeng","sequence":"additional","affiliation":[{"name":"West China School of Medicine, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng\u2010Yue","family":"Hu","sequence":"additional","affiliation":[{"name":"Laboratory of Infectious and Liver Diseases, Institute of Infectious Diseases, West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"West China School of Medicine, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Department of Guideline and Rapid Recommendation, Cochrane China Center, MAGIC China Center, Chinese Evidence\u2010Based Medicine Center, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfeng","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Central Hospital affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don C.","family":"Rockey","sequence":"additional","affiliation":[{"name":"Digestive Disease Research Center Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Tang","sequence":"additional","affiliation":[{"name":"Center of Infectious Diseases, West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"Laboratory of Infectious and Liver Diseases, Institute of Infectious Diseases, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Department of Guideline and Rapid Recommendation, Cochrane China Center, MAGIC China Center, Chinese Evidence\u2010Based Medicine Center, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(22)00165-0"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.04.036"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.05.036"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-00381-6"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32542"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.04.014"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.12.053"},{"key":"e_1_2_15_9_1","unstructured":"Medscape. 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