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This longitudinal study investigated several potential antecedents of these fear appraisals: maternal optimism, recent negative life events, lifetime history of traumatic events, and medical characteristics of the child's disease and HSCT course. One hundred\u2010forty mothers were interviewed during their child's hospitalization for HSCT and at 3\u2010and 6\u2010months post\u2010HSCT. Structural equation modeling was used to test a model of hypothesized relations. Consistent with predictions, lower optimism and a greater number of negative life events were independently associated with greater maternal fear appraisals. Contrary to expectations, lifetime history of trauma was not associated with maternal fear appraisals. Mothers' fear appraisals during their child's hospitalization were, in turn, associated with their fear appraisals up to 6 months later. These data identify a subset of mothers who may be particularly in need of an intervention to increase optimistic coping strategies, improve coping with negative life events, and reduce fear appraisals to improve their adjustment following their child's HSCT. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pon.1132","type":"journal-article","created":{"date-parts":[[2007,1,11]],"date-time":"2007-01-11T18:18:50Z","timestamp":1168539530000},"page":"821-833","source":"Crossref","is-referenced-by-count":15,"title":["Optimism and life events as predictors of fear appraisals in mothers of children undergoing hematopoietic stem cell transplantation"],"prefix":"10.1002","volume":"16","author":[{"given":"Katherine 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