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The present study offered an initial investigation of three potential predictors of patient distress: disease duration, family history of cancer, and perceived social support. Longer disease duration and stronger family history of cancer are associated with elevated CRC risk in this already high\u2010risk population. Perceived support was conceptualized as a resource that could decrease vulnerability to distress or buffer adverse psychological effects of disease duration and family history. Men and women (<jats:italic>n<\/jats:italic> = 223) with IBD participating in a colon disease family registry completed measures for this cross\u2010sectional study. Family history of CRC and non\u2010colorectal cancers among first\u2010degree relatives (FDRs) and more distant relatives (DRs) was examined separately. Hierarchical multiple regression analyses revealed that having greater perceived support predicted lower generalized distress (<jats:italic>p<\/jats:italic>&lt;0.001). Having an FDR history of CRC predicted higher CRC\u2010specific distress (<jats:italic>p<\/jats:italic> = 0.02). Having a DR history of CRC also predicted higher CRC\u2010specific distress, but only among patients diagnosed more recently (<jats:italic>p<\/jats:italic> = 0.03). Clinical implications of these findings are discussed along with future research directions. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pon.1227","type":"journal-article","created":{"date-parts":[[2007,7,2]],"date-time":"2007-07-02T17:53:31Z","timestamp":1183398811000},"page":"354-362","source":"Crossref","is-referenced-by-count":15,"title":["Distress among inflammatory bowel disease patients at high risk for colorectal cancer: a preliminary investigation of the effects of family history of cancer, disease duration, and perceived social 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