{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:15:17Z","timestamp":1792714517751,"version":"4.5.0"},"reference-count":57,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,12,21]],"date-time":"2007-12-21T00:00:00Z","timestamp":1198195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>: Unclassified variants (UVs, variants of uncertain clinical significance) are found in 13% of all BRCA1\/2 mutation analyses. Little is known about the counsellees' recall and interpretation of a UV, and its psychosocial\/medical impact.<\/jats:p><jats:p><jats:italic>Method<\/jats:italic>: Retrospective semi\u2010structured interviews with open questions and five\u2010point Likert scales were carried out in 24 counsellees who received a UV result 3 years before (sd=1.9).<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: Sixty\u2010seven percent (16\/24) <jats:italic>recalled<\/jats:italic> the UV result as a non\u2010informative DNA result; 29% recalled a pathogenic result. However, 79% of all counsellees <jats:italic>interpreted<\/jats:italic> the UV result as a genetic predisposition for cancer. Variations in recall and interpretation were unexplained by demographics, cancer history of themselves and relatives, and communication aspects of UV disclosure. Sixty\u2010seven percent perceived genetic counselling as completed, whereas 71% expected to receive new DNA information. Although most counsellees reported that UV disclosure had changed their lives <jats:italic>in general<\/jats:italic> little, one in three counsellees reported large changes in <jats:italic>specific<\/jats:italic> life domains, especially in surveillance behavior and medical decisions. Ten out of 19 participants who interpreted the UV as pathogenic had undergone preventive surgery against none of the 5 counsellees who interpreted the UV as non\u2010informative.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>: Counsellors and researchers need to address discrepancies between the counsellees' factual recall and their subjective interpretation of non\u2010informative BRCA1\/2\u2010test results. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pon.1311","type":"journal-article","created":{"date-parts":[[2007,12,21]],"date-time":"2007-12-21T13:46:25Z","timestamp":1198244785000},"page":"822-830","source":"Crossref","is-referenced-by-count":100,"title":["The counsellees' view of an unclassified variant in BRCA1\/2: recall, interpretation, and impact on life"],"prefix":"10.1002","volume":"17","author":[{"given":"Jo\u00ebl","family":"Vos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilma","family":"Otten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christi","family":"van Asperen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Menko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aad","family":"Tibben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,8,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/378789a0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7545954"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1088759"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/375033"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/301749"},{"key":"e_1_2_1_7_2","first-page":"265","article-title":"Breast and ovarian\u2010cancer incidence in brcai\u2010mutation carriers","volume":"56","author":"Easton DF","year":"1995","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.39.6.410"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/109065702761403360"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(2000)9999:999<00::AID-AJMG1142>3.0.CO;2-I"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:JOGC.0000027958.02383.a9"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201379"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/109065704323015996"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.GIM.0000159902.34833.26"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.soncn.2004.04.005"},{"key":"e_1_2_1_16_2","first-page":"106","article-title":"Het menselijk genoom bekend! Wat moeten psychologen ermee?","volume":"15","author":"ten Kroode HFJ","year":"2001","journal-title":"De Psycholoog"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.61.6.969"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1158\/1055-9965.EPI-05-0512","article-title":"No evidence of false reassurance among women with an inconclusive BRCA1\/2 genetic test result","volume":"14","author":"Dorval M","year":"2005","journal-title":"Canc Epidem Biomar"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1089\/10906570260199320"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2003.11.025"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.2.514"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.7259"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1089\/gte.2004.8.235"},{"key":"e_1_2_1_24_2","unstructured":"AlthausBW EthingtonG BlumJL.The psychological impact of a variant of uncertain significance test result in BRCA1 and BRCA2 clinical testing. American Society of Human Genetics Annual Meeting Toronto Canada 2004 Program number 1398."},{"key":"e_1_2_1_25_2","first-page":"455","article-title":"The effects on patients after receiving a result of a variant of uncertain clinical significance for BRCA1 and BRCA2 testing","volume":"11","author":"Chimera C","year":"2002","journal-title":"Genet Counsel"},{"key":"e_1_2_1_26_2","first-page":"7","article-title":"Patient's perceptions of uncertain variant results in the BRCA genes","volume":"15","author":"Rao S","year":"2006","journal-title":"Genet Counsel"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-2466.2001.tb02892.x"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.16.1.8"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.10844"},{"key":"e_1_2_1_30_2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1023\/B:FAME.0000026820.32469.4a","article-title":"BRCA1 testing with definitive results: a prospective study of psychological distress in a large clinic\u2010based sample","volume":"3","author":"Reichelt JG","year":"2004","journal-title":"Fam Cancer"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02895156"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20010101)98:1<15::AID-AJMG1014>3.0.CO;2-0"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/nur.4770170306"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950715)76:2<167::AID-CNCR2820760203>3.0.CO;2-K"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026297618180"},{"key":"e_1_2_1_36_2","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/1099-1611(200011\/12)9:6<528::AID-PON486>3.0.CO;2-#","article-title":"Cognitive representations of breast cancer. Emotional distress and preventive health behaviour: a theoretical perspective","volume":"9","author":"Decruyenaere M","year":"2000","journal-title":"Psycho\u2010Oncology"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/pon.1178"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-199705000-00010"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1097\/00125817-200209000-00006"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.12.955"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19960220)69:1<58::AID-IJC15>3.0.CO;2-G"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/pon.805"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30322"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.05.004"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1186\/1479-7364-2-1-70"},{"key":"e_1_2_1_46_2","first-page":"1730","article-title":"Statement of the American Society of Clinical Oncology: genetic testing for cancer susceptibility","volume":"14","author":"Anonymous","year":"1996","journal-title":"J Clin Oncol"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.6.1480"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1159\/000053137"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1080\/08870440008400284"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19990101)82:1<53::AID-AJMG11>3.0.CO;2-#"},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1559-1816.1997.tb01799.x"},{"key":"e_1_2_1_52_2","first-page":"326","article-title":"Feeling at risk: how do women express themselves?","volume":"10","author":"van Dijk S","year":"2002","journal-title":"Eur J Hum Genet"},{"key":"e_1_2_1_53_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.138.12.1323"},{"key":"e_1_2_1_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-005-5833-5"},{"key":"e_1_2_1_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600988"},{"key":"e_1_2_1_56_2","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.127.2.267"},{"key":"e_1_2_1_57_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0272-4332.2004.00433.x"},{"key":"e_1_2_1_58_2","doi-asserted-by":"publisher","DOI":"10.1037\/0003-066X.58.9.697"}],"container-title":["Psycho-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpon.1311","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pon.1311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T21:30:26Z","timestamp":1694640626000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pon.1311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":57,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["10.1002\/pon.1311"],"URL":"https:\/\/doi.org\/10.1002\/pon.1311","archive":["Portico"],"relation":{},"ISSN":["1057-9249","1099-1611"],"issn-type":[{"value":"1057-9249","type":"print"},{"value":"1099-1611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8]]}}}