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Major depressive disorder, generalized anxiety disorder, panic disorder, and posttraumatic stress disorder were assessed using the Structured Clinical Interview for the <jats:italic>Diagnostic and Statistical Manual of Mental Disorders\u2014IV<\/jats:italic> Axis I Disorders. Other factors examined included existential well\u2010being, patient grief about their illness, physical symptom burden, terminal illness acknowledgment, peacefulness, and the wish to live or die.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: Closeness to death was not associated with higher rates of mental disorders. Patients closer to death exhibited increased existential distress and physical symptom burden, were more likely to acknowledge being terminally ill, and were more likely to report an increased wish to die.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>: Results do not provide support for the common clinical assumption that the prevalence of depressive and anxiety disorders increases as death nears. However, patients' level of physical distress, acknowledgment of terminal illness, and wish to die, possibly reflecting acceptance of dying, increased as death approached. Longitudinal studies are needed to confirm individual changes in rates of mental disorder as patients approach death. 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