{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:06:01Z","timestamp":1791115561939,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2009,2,12]],"date-time":"2009-02-12T00:00:00Z","timestamp":1234396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>: Few data are available regarding the long\u2010term psychological impact of uninformative <jats:italic>BRCA1\/2<\/jats:italic> test results. This study examines change in distress from pretesting to 12\u2010months post\u2010disclosure, with medical, family history, and psychological variables, such as pretesting perceived risk of carrying a deleterious mutation prior to testing and primary and secondary appraisals, as predictors.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>: Two hundred and nine women with uninformative <jats:italic>BRCA1\/2<\/jats:italic> test results completed questionnaires at pretesting and 1\u2010, 6\u2010, and 12\u2010month post\u2010disclosure, including measures of anxiety and depression, cancer\u2010specific and genetic testing distress. We used a mixed models approach to predict change in post\u2010disclosure distress.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: Distress declined from pretesting to 1\u2010month post\u2010disclosure, but remained stable thereafter. Primary appraisals predicted all types of distress at 1\u2010month post\u2010disclosure. Primary and secondary appraisals predicted genetic testing distress at 1\u2010month as well as change over time. Receiving a variant of uncertain clinical significance and entering testing with a high expectation for carrying a deleterious mutation predicted genetic testing distress that persisted through the year after testing.<\/jats:p><jats:p><jats:italic>Conclusions<\/jats:italic>: As a whole, women receiving uninformative <jats:italic>BRCA1\/2<\/jats:italic> test results are a resilient group. For some women, distress experienced in the month after testing does not dissipate. Variables, such as heightened pretesting perceived risk and cognitive appraisals, predict greater likelihood for sustained distress in this group and could be amenable to intervention. 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