{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:18:13Z","timestamp":1791155893874,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2009,1,20]],"date-time":"2009-01-20T00:00:00Z","timestamp":1232409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>: Our objective is to evaluate the mental status of primary early breast cancer survivors according to DSM\u2010IV criteria, distinguishing new psychiatric diagnosis, which started after the cancer diagnosis from relapse.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>: A comparative study of 144 breast cancer survivors and 125 women without previous history of cancer was carried out. Neuropsychiatric symptomatology was assessed retrospectively using standardized psychiatric examinations (Mini International Neuropsychiatric Interview, Watson's Post\u2010Traumatic Stress Disorder Inventory) over three successive periods, \u2018before cancer\u2019 (from childhood to 3 years before the interview), \u2018around the cancer event\u2019 (the last 3 years including the time of diagnosis and treatment), and \u2018currently\u2019 (the last 2 weeks).<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: Increased rates of anxiety and mood disorders were observed following a diagnosis of breast cancer compared with controls (generalized anxiety disorder (GAD) and major depressive disorder (MDD); 10.4 vs 1.6% and 19.4 vs 8.8%, respectively). The cancer disease promoted the development of dysthymia (<jats:italic>n<\/jats:italic>=4 new cases\/6 two\u2010year prevalent cases) and PTSD (7\/7) and the re\u2010emergence of MDD (<jats:italic>n<\/jats:italic>=21 relapses\/28 three\u2010year prevalent cases) and GAD (10\/15). No improvement in serious mood disorders such as MDD (16.0 vs 7.2%) and dysthymia (4.2 vs 0%) was reported at the time of interview, more than 1.75 years (median time) after the cancer surgery, the prevalence being 2\u20134 times greater in breast cancer survivors than in controls.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>: Despite significant advances in treatment, a diagnosis of breast cancer is highly associated with various forms of psychopathology, regardless of psychiatric history, with symptoms persisting after treatment. These results may assist clinicians in planning mental healthcare for women with breast cancer. 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