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Cox regression was performed to assess whether these measures of quality of life and psychosocial functioning predicted time to additional breast cancer events and all\u2010cause mortality; hazard ratios were the measure of association.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: There were 492 additional breast cancer events and 301 deaths occurred over a median 7.3 years (range: 0.01\u201310.8 years) of follow\u2010up. In multivariate models, poorer physical health was associated with both decreased time to additional breast cancer events and all\u2010cause mortality (<jats:italic>p<\/jats:italic> trend=0.005 and 0.004, respectively), while greater hostility predicted additional breast cancer events only (<jats:italic>p<\/jats:italic> trend=0.03). None of the other psychosocial variables predicted either outcome. The hazard ratios comparing persons with poor (bottom two quintiles) to better (top three quintiles) physical health were 1.42 (95% CI: 1.16, 1.75) for decreased time to additional breast cancer events and 1.37 (95% CI: 1.08, 1.74) for all\u2010cause mortality. Potentially modifiable factors associated with poor physical health included higher body mass index, lower physical activity, lower alcohol consumption, and more insomnia (<jats:italic>p<\/jats:italic>&lt;0.05 for all).<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>: Interventions to improve physical health should be tested as a means to increase time to additional breast cancer events and mortality among breast cancer survivors. 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