{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T01:39:28Z","timestamp":1784165968338,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,9,13]],"date-time":"2011-09-13T00:00:00Z","timestamp":1315872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Toronto Ovarian Cancer Research Network"},{"name":"Kristi Piia Callum Memorial Fellowship in Ovarian Cancer Research"},{"name":"University of Toronto Open Fellowship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objective of this study was to measure the impact of prophylactic salpingo\u2010oophorectomy on health\u2010related quality of life and psychological distress in women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women who underwent prophylactic salpingo\u2010oophorectomy between August 20, 2003 and June 26, 2008 because of a BRCA1 or BRCA2 mutation were invited to participate. Participants completed three questionnaires (SF\u201012<jats:sup>\u00ae<\/jats:sup> Health Survey, Brief Symptom Inventory and the Impact of Events Scale) before prophylactic surgery and again 1\u2009year after surgery. Measures of health\u2010related quality of life, of general psychological distress and of ovarian cancer worry before and after surgery were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Few women who underwent salpingo\u2010oophorectomy experienced a worsening in physical or mental health functioning after salpingo\u2010oophorectomy. On average, women experienced less ovarian cancer\u2010specific worry after surgery; 34.3% experienced moderate to severe ovarian cancer\u2010specific distress before surgery, compared with 18.6% after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>For most women, physical and mental health\u2010related quality of life did not deteriorate after prophylactic salpingo\u2010oophorectomy, and they were less worried about ovarian cancer. A subset of women continued to experience moderate to severe cancer\u2010specific distress. Identification of these women is important in order to provide continued counseling and support. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.2041","type":"journal-article","created":{"date-parts":[[2011,9,13]],"date-time":"2011-09-13T06:20:25Z","timestamp":1315894825000},"page":"212-219","source":"Crossref","is-referenced-by-count":74,"title":["The impact of prophylactic salpingo\u2010oophorectomy on quality of life and psychological distress in women with a BRCA mutation"],"prefix":"10.1002","volume":"22","author":[{"given":"Amy","family":"Finch","sequence":"first","affiliation":[{"name":"Women's College Research Institute Women's College Hospital  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly A.","family":"Metcalfe","sequence":"additional","affiliation":[{"name":"Women's College Research Institute Women's College Hospital  Toronto ON Canada"},{"name":"Bloomberg School of Nursing University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaclyn","family":"Chiang","sequence":"additional","affiliation":[{"name":"Women's College Research Institute Women's College Hospital  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine","family":"Elit","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology McMaster University  Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"McLaughlin","sequence":"additional","affiliation":[{"name":"Samuel Lunenfeld Research Institute  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Springate","sequence":"additional","affiliation":[{"name":"BC Cancer Agency  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Jane","family":"Esplen","sequence":"additional","affiliation":[{"name":"Division of Behavioral Science &amp; Health Toronto General Research Institute  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rochelle","family":"Demsky","sequence":"additional","affiliation":[{"name":"Familial Breast and Ovarian Cancer Clinic Princess Margaret Hospital  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Murphy","sequence":"additional","affiliation":[{"name":"Familial Breast and Ovarian Cancer Clinic Princess Margaret Hospital  Toronto ON Canada"},{"name":"Department of Gynecology Oncology University Health Network, University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Rosen","sequence":"additional","affiliation":[{"name":"Familial Breast and Ovarian Cancer Clinic Princess Margaret Hospital  Toronto ON Canada"},{"name":"Department of Gynecology Oncology University Health Network, University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A.","family":"Narod","sequence":"additional","affiliation":[{"name":"Women's College Research Institute Women's College Hospital  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,9,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/301749"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199705153362001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1088759"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/375033"},{"key":"e_1_2_6_6_1","first-page":"2789","article-title":"Cancer statistics review: 1973\u20131988","volume":"91","author":"Reis LHB","year":"1991","journal-title":"National Cancer Institute, NIH Publication"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91578-4"},{"issue":"6","key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1001\/jama.1995.03520300065039","article-title":"Ovarian cancer. 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