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Allostatic load, a composite score of biomarkers representing physiologic dysregulation, may serve as a measure of the biological burden of breast cancer. This study investigates the association between breast cancer and allostatic load scores by comparing allostatic load scores in those with a history of breast cancer to those without, stratified by race.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Black and white women aged 35 to 85 were analyzed using the data from NHANES 1999\u20132008 (<jats:italic>n<\/jats:italic>\u2009=\u20094875 women, of which 188 women had a history of breast cancer). Stratified by race, we ran multivariate analyses with history of breast cancer as a predictor for elevated allostatic load while adjusting for other potentially confounding variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although a history of breast cancer was not associated with elevated allostatic load in white women, it was significantly associated with elevated allostatic load in black women after adjusting for age, income, education, insurance type, smoking status, alcohol intake, and physical activity [Odds Ratio (OR) 2.08 (95%CI 1.02, 4.22)]. Furthermore, an interaction between black and having a history of breast cancer was found to be significant in predicting elevated allostatic load scores after adjusting for demographic, behavioral, and comorbidity characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that the biological toll of breast cancer may be greater in black women than white women. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.3044","type":"journal-article","created":{"date-parts":[[2012,1,31]],"date-time":"2012-01-31T10:15:56Z","timestamp":1328004956000},"page":"621-628","source":"Crossref","is-referenced-by-count":69,"title":["Association between breast cancer and allostatic load by race: National Health and Nutrition Examination Survey 1999\u20132008"],"prefix":"10.1002","volume":"22","author":[{"given":"Victoria","family":"Parente","sequence":"first","affiliation":[{"name":"Stony Brook University Medical Center  Stony Brook NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Hale","sequence":"additional","affiliation":[{"name":"Stony Brook University Medical Center  Stony Brook NY USA"},{"name":"Preventive Medicine Stony Brook University  Stony Brook NY 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