{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T10:54:45Z","timestamp":1773226485112,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,3,26]],"date-time":"2012-03-26T00:00:00Z","timestamp":1332720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study examined whether cognitive impairment in advanced cancer patients is associated with a heightened frequency of psychiatric disorders in their primary caregivers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three hundred fifty\u2010six patient\u2010caregiver dyads were interviewed and administered the Short Portable Mental Status Questionnaire and the Structured Clinical Interview of the Diagnostic and Statistical Manual of Mental Disorders Fourth Edition approximately 3.4\u2009months before the patient's death. The Structured Clinical Interview of the Diagnostic and Statistical Manual of Mental Disorders Fourth Edition was administered to caregivers again approximately 6\u2009months after the patient's death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010six (12.9%) patients displayed signs of mild cognitive impairment at the baseline interview. After adjustment for relevant confounders, patient cognitive impairment was significantly associated with caregiver pre\u2010loss major depressive disorder [OR 6.88 (95% CI 1.32\u201335.92); <jats:italic>p<\/jats:italic>\u2009=\u20090.02], without associated increases in suicidality. There were no significant associations between patient cognitive impairment and caregiver pre\u2010loss generalized anxiety disorder, posttraumatic stress disorder, panic disorder, or grief. Likewise, there were no significant associations between patient cognitive impairment and caregiver post\u2010loss psychiatric disorders, but caregivers of cognitively impaired patients appeared to be less satisfied with the patient's manner of death (<jats:italic>p<\/jats:italic>\u2009=\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Caregivers of cognitively impaired advanced cancer patients appear at heightened risk of major depression that resolves after the patient's death. Further study with a larger sample and more sensitive longitudinal cognitive measures is indicated. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.3076","type":"journal-article","created":{"date-parts":[[2012,3,26]],"date-time":"2012-03-26T23:57:11Z","timestamp":1332806231000},"page":"952-955","source":"Crossref","is-referenced-by-count":14,"title":["Associations between cognitive impairment in advanced cancer patients and psychiatric disorders in their caregivers"],"prefix":"10.1002","volume":"22","author":[{"given":"Fremonta","family":"Meyer","sequence":"first","affiliation":[{"name":"Center for Psycho\u2010Oncology and Palliative Care Research Dana\u2010Farber Cancer Institute  Boston MA 02115 USA"},{"name":"Department of Psychiatry Brigham and Women's Hospital  Boston MA 02115 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baohui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Psycho\u2010Oncology and Palliative Care Research Dana\u2010Farber Cancer Institute  Boston MA 02115 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Gao","sequence":"additional","affiliation":[{"name":"Center for Psycho\u2010Oncology and Palliative Care Research Dana\u2010Farber Cancer Institute  Boston MA 02115 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holly G.","family":"Prigerson","sequence":"additional","affiliation":[{"name":"Center for Psycho\u2010Oncology and Palliative Care Research Dana\u2010Farber Cancer Institute  Boston MA 02115 USA"},{"name":"Department of Medical Oncology Dana\u2010Farber Cancer Institute  Boston MA 02115 USA"},{"name":"Department of Psychiatry Brigham and Women's Hospital  Boston MA 02115 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,3,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.370"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.3863"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-009-0756-6"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.43.3.183"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2006.0253"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1497.2003.30103.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2007.01307.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/gbr041"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1975.tb00927.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1987.tb04662.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhm.589"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.10106"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-006-0103-x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa035373"}],"container-title":["Psycho-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpon.3076","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pon.3076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T19:31:54Z","timestamp":1697484714000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pon.3076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,26]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1002\/pon.3076"],"URL":"https:\/\/doi.org\/10.1002\/pon.3076","archive":["Portico"],"relation":{},"ISSN":["1057-9249","1099-1611"],"issn-type":[{"value":"1057-9249","type":"print"},{"value":"1099-1611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,26]]}}}