{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T03:06:20Z","timestamp":1781579180183,"version":"3.54.5"},"reference-count":58,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,7,24]],"date-time":"2012-07-24T00:00:00Z","timestamp":1343088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Little is known about family members' interrelated decisions to seek genetic testing for breast cancer susceptibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The specific aims of this cross\u2010sectional, descriptive, cohort study were (i) to examine whether individual and family characteristics have a direct effect on women's decisions to use genetic testing for hereditary susceptibility to breast cancer and (ii) to explore whether family characteristics moderate the relationships between individual characteristics and the decision to use genetic testing. Participants were women (&gt;18\u2009years old) who (i) received genetic testing for hereditary breast cancer and who agreed to invite one of their female relatives into the study and (ii) female relatives who had NOT obtained genetic testing and were identified by pedigree analysis as having &gt;10% chances of hereditary susceptibility to breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The final sample consisted of 168 English\u2010speaking, family dyads who completed self\u2010administered, mailed surveys with validated instruments. Multivariate conditional logistic regression analyses showed that the proposed model explained 62% of the variance in genetic testing. The factors most significantly associated with genetic testing were having a personal history of cancer; perceiving genetic testing to have more benefits than barriers; having greater family hardiness; and perceiving fewer negative consequences associated with a breast cancer diagnosis. No significant interaction effects were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Findings suggest that both individual and family characteristics are associated with the decision to obtain genetic testing for hereditary breast cancer; hence, there is a need for interventions that foster a supportive family environment for patients and their high\u2010risk relatives. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.3139","type":"journal-article","created":{"date-parts":[[2012,7,24]],"date-time":"2012-07-24T06:06:03Z","timestamp":1343109963000},"page":"1336-1343","source":"Crossref","is-referenced-by-count":27,"title":["Individual and family characteristics associated with <i>BRCA1\/2<\/i> genetic testing in high\u2010risk families"],"prefix":"10.1002","volume":"22","author":[{"given":"Maria C.","family":"Katapodi","sequence":"first","affiliation":[{"name":"University of Michigan School of Nursing  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurel L.","family":"Northouse","sequence":"additional","affiliation":[{"name":"University of Michigan School of Nursing  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara J.","family":"Milliron","sequence":"additional","affiliation":[{"name":"University of Michigan Breast and Ovarian Cancer Risk Evaluation Program  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guipeng","family":"Liu","sequence":"additional","affiliation":[{"name":"University of Michigan School of Nursing  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia D.","family":"Merajver","sequence":"additional","affiliation":[{"name":"University of Michigan Breast and Ovarian Cancer Risk Evaluation Program  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0802968"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2008.212"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7939630"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7545954"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/378789a0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1088759"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.6772"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201256"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq443"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.9430"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.7888"},{"issue":"1","key":"e_1_2_8_13_1","first-page":"5","article-title":"Tamoxifen and breast cancer risk in women harboring a BRCA1 germline mutation: computed efficacy, effectiveness and impact","volume":"18","author":"Eisinger F","year":"2001","journal-title":"Int J Oncol"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.2.185"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23340"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh655"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0002"},{"key":"e_1_2_8_18_1","volume-title":"Stress, Appraisal, and Coping","author":"Lazarus RS","year":"1984"},{"key":"e_1_2_8_19_1","volume-title":"Decision Making","author":"Janis IL","year":"1977"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1545-5300.2005.00039.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.1999.550605.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:JOGC.0000027959.37096.78"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/109065703322537241"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.24.4.S78"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.5.523"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-199709000-00001"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.935"},{"key":"e_1_2_8_28_1","first-page":"1579","article-title":"Psychosocial predictors of BRCA counseling and testing decisions among urban African\u2010American women","volume":"11","author":"Thompson HS","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1547-5069.2005.00007.x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2009.33"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-010-9296-y"},{"key":"e_1_2_8_32_1","first-page":"127","article-title":"Life after BRCA1\/2 testing: family communication and support issues","author":"DeMarco TA","year":"2006","journal-title":"Breast Dis"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/10410236.2011.558338"},{"issue":"4","key":"e_1_2_8_34_1","first-page":"304","article-title":"A social network analysis of communication about hereditary nonpolyposis colorectal cancer genetic testing and family functioning","volume":"12","author":"Koehly LM","year":"2003","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2002.620204.x"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-008-0077-7"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20000814)93:4<257::AID-AJMG1>3.0.CO;2-8"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.10868"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.10110"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:JOGC.0000018824.04992.7b"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-004-7991-2"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2010.02.033"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1188\/05.ONF.617-623"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30577"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/08870440290001494"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/NCC.0b013e3181b430f9"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1545-5300.1990.00199.x"},{"key":"e_1_2_8_48_1","first-page":"639","volume-title":"Family Assessment: Resiliency, Coping, and Adaptation","author":"McCubbin HI","year":"1996"},{"key":"e_1_2_8_49_1","first-page":"239","volume-title":"FHI: Family Hardiness Index. Family assessment: Resiliency, Coping, and Adaptation","author":"McCubbin HI","year":"1996"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780100410"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-005-0412-3"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2004.09.011"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.70.3.784"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1080\/088704403100081321"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0b013e3283252d80"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30566"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0012714"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003727-200110000-00004"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-006-9078-8"}],"container-title":["Psycho-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpon.3139","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpon.3139","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pon.3139","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:10:17Z","timestamp":1697501417000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pon.3139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,24]]},"references-count":58,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1002\/pon.3139"],"URL":"https:\/\/doi.org\/10.1002\/pon.3139","archive":["Portico"],"relation":{},"ISSN":["1057-9249","1099-1611"],"issn-type":[{"value":"1057-9249","type":"print"},{"value":"1099-1611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,24]]}}}