{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:16:59Z","timestamp":1777403819898,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,10,12]],"date-time":"2012-10-12T00:00:00Z","timestamp":1350000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psycho-Oncology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Clozapine is reserved for overcoming treatment resistance in schizophrenia. Malignancy is common in schizophrenia; however, there is limited evidence available on continuing clozapine with chemotherapy, with both having hematological adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To report a case on the use of granulocyte colony\u2010stimulating factor (G\u2010CSF) in conjunction with clozapine and chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched PubMed for any available information on the use of granulocyte G\u2010CSF with clozapine and chemotherapy. We report the case of a patient with schizophrenia who developed B\u2010cell lymphoma and was treated with chemotherapy consisting of CHOP regimen, rituximab, and methotrexate. He was continued on clozapine and G\u2010CSF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We did not find any reports on G\u2010CSF use in conjunction with clozapine and chemotherapy. We found case reports and a case series on the use of G\u2010CSF in clozapine rechallenge with clozapine\u2010induced agranulocytosis with mixed results. In our patient on clozapine, the white blood cell counts reduced by chemotherapy, were successfully replenished with the use of filgrastim, a G\u2010CSF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>With risks of psychosis relapse and exacerbation with discontinuing clozapine, the addition of G\u2010CSF could be a useful aid in replenishing white cell counts lost to chemotherapy whilst continuing clozapine. However, further study is needed on this combination. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pon.3209","type":"journal-article","created":{"date-parts":[[2012,10,12]],"date-time":"2012-10-12T08:46:27Z","timestamp":1350031587000},"page":"1674-1675","source":"Crossref","is-referenced-by-count":19,"title":["Treating chemotherapy induced agranulocytosis with granulocyte colony\u2010stimulating factors in a patient on clozapine"],"prefix":"10.1002","volume":"22","author":[{"given":"Venkata","family":"Kolli","sequence":"first","affiliation":[{"name":"Creighton\u2010Nebraska Psychiatry Residency Program Omaha NE USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Denton","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center Omaha NE USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dileep","family":"Borra","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center Omaha NE USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhuri","family":"Pulluri","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center Omaha NE USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashish","family":"Sharma","sequence":"additional","affiliation":[{"name":"University of Nebraska College of Medicine Omaha NE USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,12]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24383"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/23.4.663"},{"issue":"3","key":"e_1_2_4_4_1","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/S0022-3565(24)37177-0","article-title":"Neutrophil cytotoxicity of the chemically reactive metabolite(s) of clozapine: possible role in agranulocytosis","volume":"283","author":"Williams DP","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"issue":"3","key":"e_1_2_4_5_1","first-page":"27","article-title":"Psychopharmacology research tutorial for practitioners\u2014clozapine agranulocytosis: mechanism of drug toxicity","volume":"13","author":"Robinson DS","year":"2006","journal-title":"Prim Psychiatr"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-84628-991-0_1"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.6.2188"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.1267"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2008.05.017"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.1996.tb00001.x"},{"issue":"1","key":"e_1_2_4_11_1","first-page":"111","article-title":"The treatment of clozapine\u2010associated agranulocytosis with granulocyte colony\u2010stimulating factor (G\u2010CSF)","volume":"32","author":"Chengappa KN","year":"1996","journal-title":"Psychopharmacol Bull"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.172.1.82"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.yic.0000062800.74434.6c"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/SMJ.0b013e318172f6c6"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.188.3.255"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.08081295"}],"container-title":["Psycho-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpon.3209","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pon.3209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T10:33:15Z","timestamp":1744367595000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pon.3209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,12]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1002\/pon.3209"],"URL":"https:\/\/doi.org\/10.1002\/pon.3209","archive":["Portico"],"relation":{},"ISSN":["1057-9249","1099-1611"],"issn-type":[{"value":"1057-9249","type":"print"},{"value":"1099-1611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,12]]}}}